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STU1 Stu1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852246, updated on 2-Nov-2024

Summary

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Official Symbol
STU1
Official Full Name
Stu1p
Primary source
SGD:S000000130
Locus tag
YBL034C
See related
AllianceGenome:SGD:S000000130; FungiDB:YBL034C; VEuPathDB:YBL034C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables beta-tubulin binding activity; kinetochore binding activity; and microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore and mitotic spindle assembly. Located in kinetochore; mitotic spindle midzone; and polar microtubule. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STU1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (153848..158389, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA-directed DNA polymerase alpha subunit POL12 Neighboring gene GTP cyclohydrolase II Neighboring gene Hek2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle. Pasqualone D, et al. J Cell Biol, 1994 Dec. PMID 7806575, Free PMC Article
  2. Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules. Vasileva V, et al. J Cell Biol, 2017 Jun 5. PMID 28446512, Free PMC Article
  3. Unattached kinetochores drive their own capturing by sequestering a CLASP. Kolenda C, et al. Nat Commun, 2018 Feb 28. PMID 29491436, Free PMC Article
  4. An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue. Majumdar S, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851564, Free PMC Article
  5. Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle. Yin H, et al. Mol Biol Cell, 2002 Jun. PMID 12058056, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
    Title: Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
  2. The withdrawal of Stu1, a CLASP essential for spindle integrity, from microtubules and attached kinetochores disrupts the organization of the spindle and thus allows the enhanced formation of dynamic random microtubules that span the nucleus and are ideal to capture unattached kinetochores.
    Title: Unattached kinetochores drive their own capturing by sequestering a CLASP.
  3. We show that only TOGL2 of Saccharomyces cerevisiae CLASP Stu1 binds to tubulin and is required for polymerization of spindle microtubules (MTs) in vivo.
    Title: A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.
  4. sequestering of Stu1 by detached kinetochores serves as a checkpoint that keeps spindle poles in close proximity until all kinetochores are captured
    Title: Stu1 inversely regulates kinetochore capture and spindle stability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-tubulin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinetochore binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in polar microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Stu1p
NP_009519.1
  • Microtubule plus-end-tracking non-motor protein; binds to MTs, stabilizing interpolar MT plus ends, facilitating polymerization of spindle MTs and producing an outward force on spindle poles; required for structural integrity of the mitotic spindle; binds detached kinetochores (KTs) and promotes capture; relocalizes to MTs and stabilizes the spindle once captured KTs reach a spindle pole; localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    153848..158389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178274.1 → NP_009519.1  TPA: Stu1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009519.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPW5, P38198
    UniProtKB/TrEMBL
    G2W8X4, N1P8Z8
    Conserved Domains (1) summary
    pfam12348
    Location:318 → 560
    CLASP_N; CLASP N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38198.1

Gene LinkOut

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