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SHE1 She1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852249, updated on 2-Nov-2024

Summary

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Official Symbol
SHE1
Official Full Name
She1p
Primary source
SGD:S000000127
Locus tag
YBL031W
See related
AllianceGenome:SGD:S000000127; FungiDB:YBL031W; VEuPathDB:YBL031W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables microtubule binding activity. Involved in establishment of mitotic spindle localization and mitotic spindle elongation. Located in cellular bud neck and nuclear microtubule. Is active in spindle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SHE1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (161699..162715)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase II Neighboring gene Hek2p Neighboring gene ADP/ATP carrier protein PET9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity. Ecklund KH, et al. J Cell Sci, 2021 Dec 1. PMID 34854468, Free PMC Article
  2. Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function. Denarier E, et al. Mol Biol Cell, 2021 Oct 1. PMID 34379441, Free PMC Article
  3. Microtubule cross-linking activity of She1 ensures spindle stability for spindle positioning. Zhu Y, et al. J Cell Biol, 2017 Sep 4. PMID 28794129, Free PMC Article
  4. She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain. Ecklund KH, et al. Nat Commun, 2017 Dec 15. PMID 29247176, Free PMC Article
  5. She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements. Markus SM, et al. Curr Biol, 2012 Dec 4. PMID 23142046, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. collides with and pauses motile dynein motors, prolonging their attachment to the microtubule
    Title: She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements.
  2. Data suggest that She1p restricts dynein-dependent spindle positioning to anaphase by inhibiting the association of dynein with the complete dynactin complex.
    Title: Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton HDA PubMed 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
She1p
NP_009522.1
  • Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    161699..162715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178271.1 → NP_009522.1  TPA: She1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009522.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZKR6, D6VPW8, P38200
    UniProtKB/TrEMBL
    N1P7E1
    Conserved Domains (1) summary
    pfam17077
    Location:34 → 328
    Msap1; Mitotic spindle associated protein SHE1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38200.1

Gene LinkOut

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