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gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852280, updated on 2-Nov-2024

Summary

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Official Full Name
gag-pol fusion protein
Primary source
SGD:S000002147
Locus tag
YBL005W-B
See related
AllianceGenome:SGD:S000002147; FungiDB:YBL005W-B; VEuPathDB:YBL005W-B
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (221330..226598)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ldb7p Neighboring gene drug-responsive transcription factor PDR3 Neighboring gene gag protein Neighboring gene tRNA-Ser Neighboring gene Utp20p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity. Lawler JF Jr, et al. J Virol, 2002 Jan. PMID 11739699, Free PMC Article
  2. Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase. Pandey M, et al. PLoS One, 2008 Jan 2. PMID 18167548, Free PMC Article
  3. A Ty1 integrase nuclear localization signal required for retrotransposition. Moore SP, et al. Mol Cell Biol, 1998 Feb. PMID 9448008, Free PMC Article
  4. A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization. Uzun O, et al. J Virol, 2001 Jul. PMID 11413300, Free PMC Article
  5. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA nuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in retrotransposition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transposition IEA
Inferred from Electronic Annotation
more info
  
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in retrotransposon nucleocapsid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
gag-pol fusion protein
NP_009549.1
  • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    221330..226598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180048.2 → NP_009549.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009549.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPZ6, D6VY38, Q12088, Q12490
    Conserved Domains (4) summary
    cd09272
    Location:1606 → 1742
    RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
    pfam00665
    Location:664 → 782
    rve; Integrase core domain
    pfam01021
    Location:17 → 114
    TYA; TYA transposon protein
    pfam07727
    Location:1281 → 1494
    RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12490.1

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