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NTH2 alpha,alpha-trehalase NTH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852286, updated on 2-Nov-2024

Summary

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Official Symbol
NTH2
Official Full Name
alpha,alpha-trehalase NTH2
Primary source
SGD:S000000205
Locus tag
YBR001C
See related
AllianceGenome:SGD:S000000205; FungiDB:YBR001C; VEuPathDB:YBR001C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha,alpha-trehalase activity. Involved in trehalose catabolic process. Located in mitochondrion. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NTH2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (238941..241283, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene histone H2B Neighboring gene Ecm15p Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene trans-hexaprenyltranstransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4. Wolfe KH, et al. Yeast, 1994 Apr. PMID 8091860
  2. Coupling High-Throughput and Targeted Screening for Identification of Nonobvious Metabolic Engineering Targets. Babaei M, et al. ACS Synth Biol, 2024 Jan 19. PMID 38141039, Free PMC Article
  3. Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. Nwaka S, et al. J Biol Chem, 1995 Apr 28. PMID 7730323
  4. Phenotypic features of trehalase mutants in Saccharomyces cerevisiae. Nwaka S, et al. FEBS Lett, 1995 Mar 6. PMID 7883049
  5. Evaluating cellular roles and phenotypes associated with trehalose degradation genes in Saccharomyces cerevisiae. Chen A, et al. G3 (Bethesda), 2024 Sep 9. PMID 39250759

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The behaviour of trehalase mutant strains demonstrates the participation of trehalases Nth1p, Nth2p and Ath1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
    Title: The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
  2. In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization.
    Title: New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha,alpha-trehalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha,alpha-trehalase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha,alpha-trehalase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables trehalase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in trehalose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trehalose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
alpha,alpha-trehalase NTH2
NP_009555.1
  • Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    238941..241283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178349.1 → NP_009555.1  TPA: alpha,alpha-trehalase NTH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009555.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ02, P35172
    UniProtKB/TrEMBL
    G2W909
    Conserved Domains (1) summary
    COG1626
    Location:117 → 755
    TreA; Neutral trehalase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35172.1

Gene LinkOut

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