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GRX7 glutathione-disulfide reductase GRX7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852302, updated on 18-Sep-2024

Summary

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Official Symbol
GRX7
Official Full Name
glutathione-disulfide reductase GRX7
Primary source
SGD:S000000218
Locus tag
YBR014C
See related
AllianceGenome:SGD:S000000218; FungiDB:YBR014C; VEuPathDB:YBR014C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutathione-disulfide reductase (NADPH) activity. Involved in cellular response to oxidative stress. Located in Golgi lumen and cis-Golgi network. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GRX7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (266725..267336, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene alpha-1,2-mannosyltransferase MNN2 Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, characterization and regulation of a Saccharomyces cerevisiae monothiol glutaredoxin (Grx6) gene in Schizosaccharomyces pombe. Lee JH, et al. Mol Cells, 2007 Dec 31. PMID 18182845
  2. Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway. Izquierdo A, et al. Eukaryot Cell, 2008 Aug. PMID 18503006, Free PMC Article
  3. Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins. Mesecke N, et al. Biochemistry, 2008 Feb 5. PMID 18171082
  4. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Eckers E, et al. Biochemistry, 2009 Feb 17. PMID 19166312
  5. A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance. Mesecke N, et al. Mol Biol Cell, 2008 Jun. PMID 18400945, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi lumen IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole HDA PubMed 
is_active_in fungal-type vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutathione-disulfide reductase GRX7
NP_009570.1
  • Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    266725..267336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178362.1 → NP_009570.1  TPA: glutathione-disulfide reductase GRX7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009570.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ16, P38068, Q1P9U2
    UniProtKB/TrEMBL
    A6ZKW0, C8Z408, G2W921, N1PAR0
    Conserved Domains (1) summary
    cd03419
    Location:99 → 181
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38068.1

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