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OLA1 Obg-like ATPase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852313, updated on 2-Nov-2024

Summary

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Official Symbol
OLA1
Official Full Name
Obg-like ATPase
Primary source
SGD:S000000229
Locus tag
YBR025C
See related
AllianceGenome:SGD:S000000229; FungiDB:YBR025C; VEuPathDB:YBR025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP hydrolysis activity. Acts upstream of or within positive regulation of cellular response to heat. Located in cytoplasmic stress granule. Orthologous to human OLA1 (Obg like ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OLA1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (290681..291865, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene chitin synthase CHS3 Neighboring gene putative thioredoxin peroxidase SCO2 Neighboring gene enoyl-[acyl-carrier-protein] reductase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The H2O2 stimulon in Saccharomyces cerevisiae. Godon C, et al. J Biol Chem, 1998 Aug 28. PMID 9712873
  2. Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress. Kovacs M, et al. J Lipid Res, 2023 Dec. PMID 37949369, Free PMC Article
  3. Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae. Dannenmaier S, et al. J Biol Chem, 2021 Nov. PMID 34571008, Free PMC Article
  4. A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae. Samanfar B, et al. Mol Biosyst, 2014 Apr. PMID 24535059
  5. Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. Koller-Eichhorn R, et al. J Biol Chem, 2007 Jul 6. PMID 17430889

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress.
    Title: Ola1p trafficking indicates an interaction network between mitochondria, lipid droplets, and stress granules in times of stress.
  2. Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
    Title: Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.
  3. deletion of OLA1 can increase premature stop codon bypass. It also increased the rate of protein biosynthesis measured by an inducible expression system.
    Title: A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Obg-like ATPase
NP_009581.1
  • P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; positively regulates heat shock response; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    290681..291865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178373.1 → NP_009581.1  TPA: Obg-like ATPase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ27, P38219
    UniProtKB/TrEMBL
    A6ZKX1, B3LNB8, B5VDZ5, C7GM27, C8Z419, G2W932, N1P9C5
    Conserved Domains (1) summary
    PTZ00258
    Location:1 → 393
    PTZ00258; GTP-binding protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38219.1

Gene LinkOut

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