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CST26 putative acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852330, updated on 17-May-2024

Summary

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Gene symbol
CST26
Gene description
putative acyltransferase
Primary source
FungiDB:YBR042C
Locus tag
YBR042C
See related
SGD:S000000246; AllianceGenome:SGD:S000000246; VEuPathDB:YBR042C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSI1
Summary
Enables acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling. Located in lipid droplet. Orthologous to several human genes including LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CST26 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (320416..321609, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Fig1p Neighboring gene long-chain fatty acid transporter FAT1 Neighboring gene Qdr3p Neighboring gene Tcm62p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast. Le Guédard M, et al. FEBS J, 2009 Nov. PMID 19796168
  2. Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. Doignon F, et al. Mol Cell Biol, 2016 Feb 16. PMID 26711260, Free PMC Article
  3. Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay. Shui G, et al. PLoS One, 2010 Aug 4. PMID 20694142, Free PMC Article
  4. The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p. De Smet CH, et al. Mol Biol Cell, 2012 Apr. PMID 22323296, Free PMC Article
  5. The roles of thiol oxidoreductases in yeast replicative aging. Hacioglu E, et al. Mech Ageing Dev, 2010 Nov-Dec. PMID 20934449, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast.
    Title: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet HDA PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative acyltransferase
NP_009598.1
  • Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    320416..321609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178390.1 → NP_009598.1  TPA: putative acyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009598.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ42, P38226
    UniProtKB/TrEMBL
    A0A6A5PZY1, C7GXX0, G2W947, N1P802
    Conserved Domains (2) summary
    cd07990
    Location:103 → 314
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:300 → 372
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38226.1

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