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RFS1 flavodoxin-like fold family protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852341, updated on 2-Nov-2024

Summary

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Official Symbol
RFS1
Official Full Name
flavodoxin-like fold family protein
Primary source
SGD:S000000256
Locus tag
YBR052C
See related
AllianceGenome:SGD:S000000256; FungiDB:YBR052C; VEuPathDB:YBR052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable FMN binding activity and oxidoreductase activity. Acts upstream of or within positive regulation of ferroptosis. Located in cytoplasm and eisosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RFS1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (338720..339352, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-binding protein REB1 Neighboring gene protein phosphatase regulator REG2 Neighboring gene uncharacterized protein Neighboring gene Yro2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism. Cardona F, et al. Arch Microbiol, 2011 Jul. PMID 21442317
  2. Ferroptosis-protective membrane domains in quiescence. Megarioti AH, et al. Cell Rep, 2023 Dec 26. PMID 38096056
  3. The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Pedroso N, et al. Free Radic Res, 2012 Oct. PMID 22712517
  4. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
  5. Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. Valencia-Burton M, et al. Genetics, 2006 Sep. PMID 16782999, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YCP4 and RFS1 have a clear role in the regulation of metabolism at the late stages of growth.
    Title: The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of ferroptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in eisosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flavodoxin-like fold family protein
NP_009608.1
  • hypothetical protein; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    338720..339352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178400.1 → NP_009608.1  TPA: flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ51, P38234
    UniProtKB/TrEMBL
    A6ZKZ5, B3LN97, C7GST8, D3UEE7, G2W957, N1P810
    Conserved Domains (1) summary
    cl00438
    Location:1 → 201
    FMN_red; NADPH-dependent FMN reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38234.1

Gene LinkOut

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