U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSC3 Tsc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852350, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TSC3
Official Full Name
Tsc3p
Primary source
SGD:S000007521
Locus tag
YBR058C-A
See related
AllianceGenome:SGD:S000007521; FungiDB:YBR058C-A; VEuPathDB:YBR058C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme activator activity. Involved in 3-keto-sphinganine metabolic process and positive regulation of sphingolipid biosynthetic process. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TSC3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (356324..356566, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Mum2p Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene serine/threonine protein kinase AKL1 Neighboring gene origin recognition complex subunit 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Monaghan E, et al. Yeast, 2002 Jun 15. PMID 12185836
  2. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. Ren J, et al. J Lipid Res, 2018 Nov. PMID 30154231, Free PMC Article
  3. Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Xie T, et al. Cell Rep, 2024 Feb 27. PMID 38285738
  4. Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable K, et al. J Biol Chem, 2000 Mar 17. PMID 10713067
  5. Structure of the ceramide-bound SPOTS complex. Schäfer JH, et al. Nat Commun, 2023 Oct 4. PMID 37794019, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3-keto-sphinganine metabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of serine palmitoyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Tsc3p
NP_116327.3
  • Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    356324..356566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184442.3 → NP_116327.3  TPA: Tsc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116327.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ58, Q3E790
    UniProtKB/TrEMBL
    A6ZL03, B3LN90, C7GQH4, D3UEF6, G2W964
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E790.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools