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TRM7 tRNA methyltransferase TRM7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852353, updated on 2-Nov-2024

Summary

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Official Symbol
TRM7
Official Full Name
tRNA methyltransferase TRM7
Primary source
SGD:S000000265
Locus tag
YBR061C
See related
AllianceGenome:SGD:S000000265; FungiDB:YBR061C; VEuPathDB:YBR061C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA 2'-O-methyltransferase activity. Involved in cytoplasmic translation and wobble position ribose methylation. Located in cytoplasm. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TRM7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (364787..365719, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase AKL1 Neighboring gene origin recognition complex subunit 2 Neighboring gene uncharacterized protein Neighboring gene Cnm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. Cavaillé J, et al. RNA, 1999 Jan. PMID 9917067, Free PMC Article
  2. Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Guy MP, et al. Hum Mutat, 2015 Dec. PMID 26310293, Free PMC Article
  3. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. Pintard L, et al. EMBO J, 2002 Apr 2. PMID 11927565, Free PMC Article
  4. Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Hirata A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31586407, Free PMC Article
  5. A novel assay provides insight into tRNAPhe retrograde nuclear import and re-export in S. cerevisiae. Nostramo RT, et al. Nucleic Acids Res, 2020 Nov 18. PMID 33074312, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
    Title: Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA 2'-O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA nucleoside ribose methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA nucleoside ribose methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in wobble position ribose methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wobble position ribose methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA methyltransferase TRM7
NP_009617.3
  • 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    364787..365719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178409.3 → NP_009617.3  TPA: tRNA methyltransferase TRM7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009617.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ61, P38238
    UniProtKB/TrEMBL
    A6ZL06, B3LN87, B5VE27, C7GQH7, D3UEF9, G2W967, N1P9D8
    Conserved Domains (1) summary
    COG0293
    Location:1 → 211
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38238.1

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