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TAT1 amino acid transporter TAT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852361, updated on 2-Nov-2024

Summary

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Official Symbol
TAT1
Official Full Name
amino acid transporter TAT1
Primary source
SGD:S000000273
Locus tag
YBR069C
See related
AllianceGenome:SGD:S000000273; FungiDB:YBR069C; VEuPathDB:YBR069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TAP1; VAP1
Summary
Enables low-affinity tryptophan transmembrane transporter activity. Involved in transmembrane transport; tryptophan transport; and tyrosine transport. Located in plasma membrane. Orthologous to human SLC7A4 (solute carrier family 7 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TAT1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (376574..378433, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative lipase Neighboring gene branched-chain amino acid permease BAP2 Neighboring gene ncRNA Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Bajmoczi M, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473505
  2. Volatile anesthetics affect nutrient availability in yeast. Palmer LK, et al. Genetics, 2002 Jun. PMID 12072454, Free PMC Article
  3. Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. He C, et al. PLoS Genet, 2014 Dec. PMID 25521617, Free PMC Article
  4. Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Schmidt A, et al. Mol Cell Biol, 1994 Oct. PMID 7523855, Free PMC Article
  5. The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Heitman J, et al. Mol Cell Biol, 1993 Aug. PMID 7687745, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
    Title: Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
  2. Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
    Title: Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
  3. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
    Title: A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
  4. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
    Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
  5. Tup1p bound to the promoter region of TAT1 and TAT2 genes that were dependent on STP1 and STP2 (encoding DNA-binding activator proteins) for expression.
    Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables low-affinity tryptophan transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tyrosine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
amino acid transporter TAT1
NP_009625.1
  • Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    376574..378433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178417.1 → NP_009625.1  TPA: amino acid transporter TAT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ68, P38085
    UniProtKB/TrEMBL
    G2W974, N1P8B9
    Conserved Domains (1) summary
    TIGR00913
    Location:91 → 567
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38085.1

Gene LinkOut

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