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Ptp4a2 protein tyrosine phosphatase 4A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85237, updated on 2-Nov-2024

Summary

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Official Symbol
Ptp4a2provided by RGD
Official Full Name
protein tyrosine phosphatase 4A2provided by RGD
Primary source
RGD:619786
See related
EnsemblRapid:ENSRNOG00000050044 AllianceGenome:RGD:619786
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in early endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 2304.0), Spleen (RPKM 1128.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptp4a2 in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147449733..147476739)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142165405..142192412)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148035501..148060752)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene uncharacterized LOC120103178 Neighboring gene uncharacterized LOC134486996 Neighboring gene SPOC domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of a novel rat protein tyrosine phosphatase gene. Carter DA. Biochim Biophys Acta, 1998 Nov 8. PMID 9805001
  2. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase type IVA 2
Names
PRL-2
protein tyrosine phosphatase type IVA, member 2
protein-tyrosine phosphatase of regenerating liver 2
NP_445927.2
XP_017449153.1
XP_017449154.1
XP_038966808.1
XP_038966809.1
XP_063144583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053475.2 → NP_445927.2  protein tyrosine phosphatase type IVA 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A0A8I6G2R3, A6ISM1
    Related
    ENSRNOP00000064832.1, ENSRNOT00000074415.4
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    147449733..147476739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110880.2 → XP_038966808.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A0A8I6G2R3, A6ISM1
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

  2. XM_017593665.3 → XP_017449154.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A0A8I6G2R3, A6ISM1
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

  3. XM_063288513.1 → XP_063144583.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A6ISM1

  4. XM_039110881.2 → XP_038966809.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A0A8I6G2R3, A6ISM1
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

  5. XM_017593664.3 → XP_017449153.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O88765, Q6P9X4
    UniProtKB/TrEMBL
    A0A8I6G2R3, A6ISM1
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9X4.1 GenPept UniProtKB/Swiss-Prot:Q6P9X4

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