EXO84 exocyst subunit EXO84 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EXO84
Official Full Name: exocyst subunit EXO84
Primary source: SGD:S000000306
Locus tag: YBR102C
See related: AllianceGenome:SGD:S000000306; FungiDB:YBR102C; VEuPathDB:YBR102C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: USA3
Summary: Involved in Golgi to plasma membrane transport; exocyst localization; and protein-containing complex assembly. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of exocyst. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See EXO84 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (445062..447323, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitotic phosphorylation of Exo84 disrupted the assembly of the exocyst complex, thereby affecting exocytosis and cell surface expansion.
Title: Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth.
The structure of the exocyst subunit Exo84p is presented.
Title: The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif.
exocyst component Exo84p plays a critical role in both the assembly of the exocyst and its targeting to sites of secretion
Title: The critical role of Exo84p in the organization and polarized localization of the exocyst complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocyst assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal complex assembly	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in prospore membrane	HDA more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exocyst subunit EXO84

NP_009660.1

Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting of the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

445062..447323 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178450.1 → NP_009660.1 TPA: exocyst subunit EXO84 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQA1, P38261

UniProtKB/TrEMBL

A6ZL47, B3LN51, G2W9A7, N1P6L6

Conserved Domains (4) summary

pfam05109
Location:19 → 181

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam08700
Location:177 → 259

Vps51; Vps51/Vps67

pfam16528
Location:534 → 738

Exo84_C; Exocyst component 84 C-terminal

cl17171
Location:340 → 444

PH-like; Pleckstrin homology-like domain