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Pola1 DNA polymerase alpha 1, catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 85241, updated on 2-Nov-2024

Summary

Official Symbol
Pola1provided by RGD
Official Full Name
DNA polymerase alpha 1, catalytic subunitprovided by RGD
Primary source
RGD:621816
See related
EnsemblRapid:ENSRNOG00000013322 AllianceGenome:RGD:621816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 160.2), Spleen (RPKM 111.7) and 9 other tissues See more
Orthologs
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Genomic context

See Pola1 in Genome Data Viewer
Location:
Xq22
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62028475..62342455, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58034617..58348612, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (62382604..62698830, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099281 Neighboring gene aristaless related homeobox Neighboring gene solute carrier family 30 member 9, pseudogene 1 Neighboring gene small Cajal body-specific RNA 24 Neighboring gene phosphate cytidylyltransferase 1B, choline Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 4 Neighboring gene pyruvate dehydrogenase kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleotide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pyrimidine nucleotide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication, synthesis of primer ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA strand elongation involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA strand elongation involved in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in DNA synthesis involved in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in DNA synthesis involved in UV-damage excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lagging strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in lagging strand elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leading strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in leading strand elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of alpha DNA polymerase:primase complex IC
Inferred by Curator
more info
PubMed 
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
 
part_of alpha DNA polymerase:primase complex ISO
Inferred from Sequence Orthology
more info
 
part_of alpha DNA polymerase:primase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA polymerase alpha catalytic subunit
Names
DNA polymerase alpha catalytic subunit p180
DNA polymerase alpha subunit I
polymerase (DNA directed), alpha 1, catalytic subunit
polymerase (DNA) alpha 1, catalytic subunit
NP_445931.1
XP_038956049.1
XP_038956050.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053479.1NP_445931.1  DNA polymerase alpha catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    AI511322, AJ011605, CN543332, FM076387
    UniProtKB/Swiss-Prot
    O89042
    Related
    ENSRNOP00000068341.2, ENSRNOT00000075997.4
    Conserved Domains (5) summary
    cd05776
    Location:542774
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8391249
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:561232
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12721461
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:41101
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    62028475..62342455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100121.2XP_038956049.1  DNA polymerase alpha catalytic subunit isoform X1

    Conserved Domains (1) summary
    TIGR00592
    Location:56989
    pol2; DNA polymerase (pol2)
  2. XM_039100122.1XP_038956050.1  DNA polymerase alpha catalytic subunit isoform X2

    Conserved Domains (1) summary
    TIGR00592
    Location:56857
    pol2; DNA polymerase (pol2)