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RAD16 DNA repair protein RAD16 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852411, updated on 2-Nov-2024

Summary

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Official Symbol
RAD16
Official Full Name
DNA repair protein RAD16
Primary source
SGD:S000000318
Locus tag
YBR114W
See related
AllianceGenome:SGD:S000000318; FungiDB:YBR114W; VEuPathDB:YBR114W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSO5
Summary
Contributes to ATP-dependent activity, acting on DNA and ubiquitin-protein transferase activity. Involved in nucleotide-excision repair, DNA damage recognition; protein localization; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex and nucleotide-excision repair factor 4 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAD16 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (467248..469620)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sus1p Neighboring gene transcription regulator CYC8 Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene transketolase TKL2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of RAD16, a gene involved in differential repair in Saccharomyces cerevisiae. Bang DD, et al. Nucleic Acids Res, 1992 Aug 11. PMID 1508678, Free PMC Article
  2. Identification of RAD16, a yeast excision repair gene homologous to the recombinational repair gene RAD54 and to the SNF2 gene involved in transcriptional activation. Schild D, et al. Yeast, 1992 May. PMID 1626430
  3. Differential repair of UV damage in rad mutants of Saccharomyces cerevisiae: a possible function of G2 arrest upon UV irradiation. Terleth C, et al. Mol Cell Biol, 1990 Sep. PMID 2201899, Free PMC Article
  4. Inducible nucleotide excision repair (NER) of UV-induced cyclobutane pyrimidine dimers in the cell cycle of the budding yeast Saccharomyces cerevisiae: evidence that inducible NER is confined to the G1 phase of the mitotic cell cycle. Scott AD, et al. Mol Gen Genet, 1997 Mar 18. PMID 9108289
  5. Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae. Querol CB, et al. Curr Genet, 1994 May. PMID 8082185

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-137 was able to promote sensitivity of PC cells to chemotherapy via inhibition of autophagy mediated by ATG5
    Title: Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex.
  2. use of rad7 Delta rad16 Delta mutants showed that Rad7-Rad16 is required for nucleotide excision repair of UV-lesions in three functionally distinct nucleosome-free regions, the promoter and 3'-end of the URA3 gene and the ARS1 origin of replication
    Title: Functionally distinct nucleosome-free regions in yeast require Rad7 and Rad16 for nucleotide excision repair.
  3. Rad16 mediates the ultraviolet-induced acetylation of histone H3, necessary for efficient global genome nucleotide-excision repair.
    Title: Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair.
  4. Rad16 is solely responsible for repairing the nontranscribed strand of actively transcribed genes
    Title: The roles of Rad16 and Rad26 in repairing repressed and actively transcribed genes in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA damage recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair, DNA damage recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-excision repair factor 4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein RAD16
NP_009672.1
  • Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    467248..469620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178462.1 → NP_009672.1  TPA: DNA repair protein RAD16 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009672.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQB3, P31244
    UniProtKB/TrEMBL
    B3LN39, B5VE76, C7GUL1, D3UEK7, G2W9C0, N1P867
    Conserved Domains (2) summary
    COG0553
    Location:55 → 788
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    COG5432
    Location:537 → 642
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31244.1

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