TPS1 alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TPS1
Gene description: alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1
Primary source: FungiDB:YBR126C
Locus tag: YBR126C
See related: SGD:S000000330; AllianceGenome:SGD:S000000330; VEuPathDB:YBR126C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BYP1; CIF1; FDP1; GGS1; GLC6; TSS1
Summary: Enables trehalose-phosphatase activity. Contributes to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity. Involved in several processes, including cellular response to desiccation; cellular response to heat; and trehalose biosynthetic process. Located in cytoplasm. Part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TPS1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (488905..490392, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipophilic Cations Rescue the Growth of Yeast under the Conditions of Glycolysis Overflow.
Title: Lipophilic Cations Rescue the Growth of Yeast under the Conditions of Glycolysis Overflow.
MAL62 and TPS1 overexpression in the NTH1 deletion background further strengthened freezing tolerance and improved leavening ability.
Title: MAL62 Overexpression Enhances Freezing Tolerance of Baker's Yeast in Lean Dough by Enhancing Tps1 Activity and Maltose Metabolism.
Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.
Title: Regulation of the yeast trehalose-synthase complex by cyclic AMP-dependent phosphorylation.
Results suggest that a complex regulatory network, involving transcription factors and other regulatory proteins, underpins the phenotypic alterations in potato when expressing the TPS1 gene of yeast.
Title: Transcriptome analysis of potato leaves expressing the trehalose-6-phosphate synthase 1 gene of yeast.
Purified trehalose-6-phosphate synthase (TPS) of Saccharomyces cerevisiae was effective over a wide range of substrates, although differing with regard to their relative activity.
Title: Studies on substrate specificity and activity regulating factors of trehalose-6-phosphate synthase of Saccharomyces cerevisiae.
Active TPS has been isolated from the trehalose synthase complex as a free 59 kDa protein and characterized.
Title: Aggregation dependent enhancement of trehalose-6-phosphate synthase activity in Saccharomyces cerevisiae.
Two transgenic potato lines, T1 and T2, expressing the trehalose-6-phosphate synthase (TPS1) gene of yeast were isolated; water metabolism in these potato lines were reported.
Title: Effects of drought on water content and photosynthetic parameters in potato plants expressing the trehalose-6-phosphate synthase gene of Saccharomyces cerevisiae.
We showed that a tps1 mutant defective in the TPS catalytic subunit cultivated on trehalose, or on a dual source of carbon made of galactose and trehalose, accumulated high levels of intracellular trehalose by its Agt1p-mediated transport.
Title: New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.
Gts1p plays a major role in the oscillatory expression of TPS1 and SUC2 in continuous cultures of Saccharomyces cerevisiae.
Title: Gts1p stabilizes oscillations in energy metabolism by activating the transcription of TPS1 encoding trehalose-6-phosphate synthase 1 in the yeast Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IEA Inferred from Electronic Annotation more info
contributes_to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables trehalose-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to desiccation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in trehalose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose metabolism in response to stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IDA Inferred from Direct Assay more info	PubMed
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IMP Inferred from Mutant Phenotype more info	PubMed
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1

NP_009684.1

EC 2.4.1.15

Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid; required for pseudohyphal growth