VMA2 H(+)-transporting V1 sector ATPase subunit B [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VMA2
Official Full Name: H(+)-transporting V1 sector ATPase subunit B
Primary source: SGD:S000000331
Locus tag: YBR127C
See related: AllianceGenome:SGD:S000000331; FungiDB:YBR127C; VEuPathDB:YBR127C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: VAT2
Summary: Enables proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including intracellular monoatomic cation homeostasis; pexophagy; and proteasome storage granule assembly. Located in fungal-type vacuole membrane; membrane raft; and vacuole-mitochondrion membrane contact site. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Used to study follicular lymphoma and renal tubular acidosis. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to several human genes including ATP6V1B1 (ATPase H+ transporting V1 subunit B1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VMA2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (491269..492822, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mossbauer and LC-ICP-MS investigation of iron trafficking between vacuoles and mitochondria in vma2DeltaSaccharomyces cerevisiae.
Title: Mössbauer and LC-ICP-MS investigation of iron trafficking between vacuoles and mitochondria in vma2ΔSaccharomyces cerevisiae.
These findings suggest a role for vacuolar proton translocation ATPase in the regulation of the cell wall stress response and the prevention of endogenous oxidative stress in response to ethanol.
Title: Vacuolar H+-ATPase Protects Saccharomyces cerevisiae Cells against Ethanol-Induced Oxidative and Cell Wall Stresses.
Inorganic polyphosphate in the yeast Saccharomyces cerevisiae with a mutation disturbing the function of vacuolar ATPase
Title: Inorganic polyphosphate in the yeast Saccharomyces cerevisiae with a mutation disturbing the function of vacuolar ATPase.
These results suggest that actin-binding activity confers on the B subunit of yeast a function that is distinct from its role in the enzymatic activity of the proton pump.
Title: Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.
The results showed that intracellular acidification was induced during air-drying and that this acidification was amplified in a deletion mutant of the VMA2 gene encoding a component of vacuolar H(+)-ATPase.
Title: Possible roles of vacuolar H+-ATPase and mitochondrial function in tolerance to air-drying stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome storage granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: H(+)-transporting V1 sector ATPase subunit B

NP_009685.3

Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

491269..492822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178475.3 → NP_009685.3 TPA: H(+)-transporting V1 sector ATPase subunit B [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009685.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQC4, P16140, P32123

UniProtKB/TrEMBL

A6ZL71, B3LN29, C7GY10, D3UEM1, G2W9D1, N1P9H0

Conserved Domains (1) summary

TIGR01040
Location:27 → 485

V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit