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ATG14 Atg14p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852425, updated on 2-Nov-2024

Summary

Official Symbol
ATG14
Official Full Name
Atg14p
Primary source
SGD:S000000332
Locus tag
YBR128C
See related
AllianceGenome:SGD:S000000332; FungiDB:YBR128C; VEuPathDB:YBR128C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APG14; CVT12
Summary
Involved in cellular response to potassium ion starvation; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in fungal-type vacuole membrane; phagophore assembly site; and vacuole-isolation membrane contact site. Part of phosphatidylinositol 3-kinase complex, class III, type I. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ATG14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (493081..494115, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Meo1p Neighboring gene H(+)-transporting V1 sector ATPase subunit B Neighboring gene Opy1p Neighboring gene She3p

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to potassium ion starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
 
part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole-isolation membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Atg14p
NP_009686.1
  • Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    493081..494115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178476.1NP_009686.1  TPA: Atg14p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC5, P38270
    UniProtKB/TrEMBL
    B3LN28, B5VE88, C7GY11, N1P879
    Conserved Domains (1) summary
    pfam10186
    Location:3224
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14