U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ATG14 Atg14p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852425, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ATG14
Official Full Name
Atg14p
Primary source
SGD:S000000332
Locus tag
YBR128C
See related
AllianceGenome:SGD:S000000332; FungiDB:YBR128C; VEuPathDB:YBR128C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APG14; CVT12
Summary
Involved in cellular response to potassium ion starvation; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in fungal-type vacuole membrane; phagophore assembly site; and vacuole-isolation membrane contact site. Part of phosphatidylinositol 3-kinase complex, class III, type I. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ATG14 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (493081..494115, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Meo1p Neighboring gene H(+)-transporting V1 sector ATPase subunit B Neighboring gene Opy1p Neighboring gene She3p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Autophagy-related protein MoAtg14 is involved in differentiation, development and pathogenicity in the rice blast fungus Magnaporthe oryzae. Liu XH, et al. Sci Rep, 2017 Jan 9. PMID 28067330, Free PMC Article
  2. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. Kametaka S, et al. J Biol Chem, 1998 Aug 28. PMID 9712845
  3. What the N-terminal domain of Atg13 looks like and what it does: a HORMA fold required for PtdIns 3-kinase recruitment. Jao CC, et al. Autophagy, 2013 Jul. PMID 23670046, Free PMC Article
  4. Autophagy regulator Atg9 is degraded by the proteasome. Hu G, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31759633, Free PMC Article
  5. Regulation of APG14 expression by the GATA-type transcription factor Gln3p. Chan TF, et al. J Biol Chem, 2001 Mar 2. PMID 11096087

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (micro-lipophagy), in which fat is metabolized as an alternative energy source. AMP-activated protein kinase (AMPK) activation triggered this pathway, which required Atg14p.
    Title: AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation.
  2. Deletion analysis of Atg14p revealed that N-terminal region containing the coiled-coil structures was essential and sufficient for autophagy.
    Title: Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to potassium ion starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-isolation membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Atg14p
NP_009686.1
  • Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    493081..494115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178476.1 → NP_009686.1  TPA: Atg14p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC5, P38270
    UniProtKB/TrEMBL
    B3LN28, B5VE88, C7GY11, N1P879
    Conserved Domains (1) summary
    pfam10186
    Location:3 → 224
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38270.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools