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BMT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852438, updated on 22-Aug-2024

Summary

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Official Symbol
BMT2
Primary source
FungiDB:YBR141C
Locus tag
YBR141C
See related
SGD:S000000345; AllianceGenome:SGD:S000000345; VEuPathDB:YBR141C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA (adenine) methyltransferase activity. Predicted to be involved in rRNA methylation. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (527025..528038, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene carboxypeptidase C Neighboring gene GTPase-activating protein IRA1 Neighboring gene putative ATP-dependent RNA helicase Neighboring gene translation termination factor eRF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-content screening of yeast mutant libraries by shotgun lipidomics. Tarasov K, et al. Mol Biosyst, 2014 Jun. PMID 24681539
  2. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. Sharma S, et al. Nucleic Acids Res, 2013 May 1. PMID 23558746, Free PMC Article
  3. Multiple Motif Scanning to identify methyltransferases from the yeast proteome. Petrossian TC, et al. Mol Cell Proteomics, 2009 Jul. PMID 19351663, Free PMC Article
  4. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article
  5. Structural and functional analysis of ribosome assembly factor Efg1. Shu S, et al. Nucleic Acids Res, 2018 Feb 28. PMID 29361028, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reports the identification of a new gene YBR141C [BMT2, (base methyltransferase of 25S RNA)] responsible for m1A2142 base modification of helix 65 in 25S rRNA of S. cerevisiae.
    Title: Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
25S rRNA (adenine2142-N1)-methyltransferase
NP_009699.2
  • Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; null mutant exhibits abnormal lipid metabolic phenotype; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    527025..528038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178489.2 → NP_009699.2  TPA: 25S rRNA (adenine2142-N1)-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009699.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQD7, P38278
    UniProtKB/TrEMBL
    A6ZL84, G2W9E4, N1P9H6
    Conserved Domains (1) summary
    pfam11968
    Location:125 → 335
    Bmt2; 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38278.2

Gene LinkOut

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