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SPP381 U4/U6-U5 snRNP complex subunit SPP381 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852449, updated on 18-Sep-2024

Summary

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Official Symbol
SPP381
Official Full Name
U4/U6-U5 snRNP complex subunit SPP381
Primary source
SGD:S000000356
Locus tag
YBR152W
See related
AllianceGenome:SGD:S000000356; FungiDB:YBR152W; VEuPathDB:YBR152W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in generation of catalytic spliceosome for first transesterification step. Located in cytosol and nucleus. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPP381 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (546376..547251)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tbs1p Neighboring gene Apd1p Neighboring gene 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase Neighboring gene DNA-directed RNA polymerase core subunit RPB5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation. Lybarger S, et al. Mol Cell Biol, 1999 Jan. PMID 9858581, Free PMC Article
  2. Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. Salas-Armenteros I, et al. Cell Rep, 2019 Aug 6. PMID 31390568, Free PMC Article
  3. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
  4. Inhibition of a spliceosome turnover pathway suppresses splicing defects. Pandit S, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945917, Free PMC Article
  5. Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Low JK, et al. Proteomics, 2016 Feb. PMID 26572822

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for first transesterification step IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit SPP381
NP_009710.3
  • mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; temperature-sensitive phenotype of prp38-1 mutant can be suppressed by human homolog of SPP381, MFAP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    546376..547251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178500.3 → NP_009710.3  TPA: U4/U6-U5 snRNP complex subunit SPP381 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009710.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQE7, P38282
    UniProtKB/TrEMBL
    B3LN07, D3UEP6, G2W9F4, N1P6S9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38282.1

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