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ECM31 3-methyl-2-oxobutanoate hydroxymethyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852474, updated on 17-May-2024

Summary

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Gene symbol
ECM31
Gene description
3-methyl-2-oxobutanoate hydroxymethyltransferase
Primary source
FungiDB:YBR176W
Locus tag
YBR176W
See related
SGD:S000000380; AllianceGenome:SGD:S000000380; VEuPathDB:YBR176W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity. Involved in pantothenate biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ECM31 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (583720..584658)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ump1p Neighboring gene Swd3p Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase Neighboring gene mitofusin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and application of a gene complementing pantothenic acid auxotrophy of sake yeast Kyokai no. 7. Shimoi H, et al. J Biosci Bioeng, 2000. PMID 16232925
  2. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
  3. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White WH, et al. J Biol Chem, 2001 Apr 6. PMID 11154694
  4. Improving isobutanol production with the yeast Saccharomyces cerevisiae by successively blocking competing metabolic pathways as well as ethanol and glycerol formation. Wess J, et al. Biotechnol Biofuels, 2019. PMID 31303893, Free PMC Article
  5. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Entian KD, et al. Mol Gen Genet, 1999 Dec. PMID 10628851

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pantothenate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pantothenate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-methyl-2-oxobutanoate hydroxymethyltransferase
NP_009735.3
  • Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    583720..584658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178524.3 → NP_009735.3  TPA: 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009735.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQH1, P38122
    UniProtKB/TrEMBL
    A0A8H4F9F4, C7GUJ0, G2W9H8
    Conserved Domains (1) summary
    COG0413
    Location:25 → 300
    PanB; Ketopantoate hydroxymethyltransferase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38122.1

Gene LinkOut

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