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YPC1 phytoceramidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852481, updated on 18-Sep-2024

Summary

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Official Symbol
YPC1
Official Full Name
phytoceramidase
Primary source
SGD:S000000387
Locus tag
YBR183W
See related
AllianceGenome:SGD:S000000387; FungiDB:YBR183W; VEuPathDB:YBR183W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phytoceramidase activity and sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process and ceramide catabolic process. Located in cortical endoplasmic reticulum. Used to study leukodystrophy. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPC1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (596115..597065)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Smp1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mba1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane topology of yeast alkaline ceramidase YPC1. Ramachandra N, et al. Biochem J, 2013 Jun 15. PMID 23445175
  2. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. Mao C, et al. J Biol Chem, 2000 Mar 10. PMID 10702247
  3. Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Pata MO, et al. Plant J, 2008 Sep. PMID 18547394, Free PMC Article
  4. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. Mao C, et al. J Biol Chem, 2000 Oct 6. PMID 10900202
  5. Sphingolipids function as downstream effectors of a fungal PAQR. Villa NY, et al. Mol Pharmacol, 2009 Apr. PMID 19066337, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-acylsphingosine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylsphingosine amidohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine N-acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables sphingosine N-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ceramide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phytoceramidase
NP_009742.1
  • Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    596115..597065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178531.1 → NP_009742.1  TPA: phytoceramidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQH8, P38298
    UniProtKB/TrEMBL
    A6ZLC4, B3LMX8, C7GQ29, D3UES7, G2W9I5, N1P9J6
    Conserved Domains (1) summary
    pfam05875
    Location:15 → 285
    Ceramidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38298.1

Gene LinkOut

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