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NTC20 Ntc20p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852486, updated on 28-Oct-2024

Summary

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Official Symbol
NTC20
Official Full Name
Ntc20p
Primary source
SGD:S000000392
Locus tag
YBR188C
See related
AllianceGenome:SGD:S000000392; FungiDB:YBR188C; VEuPathDB:YBR188C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to contribute to first spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Part of Prp19 complex and U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See NTC20 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (603685..604107, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Pch2p Neighboring gene putative ribosome biosynthesis protein GDT1 Neighboring gene ribosomal 40S subunit protein S9B Neighboring gene ribosomal 60S subunit protein L21A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing. Chen HR, et al. Proc Natl Acad Sci U S A, 1999 May 11. PMID 10318896, Free PMC Article
  2. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Villa T, et al. Genes Dev, 2005 Aug 15. PMID 16103217, Free PMC Article
  3. DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps. Tseng CK, et al. RNA, 2011 Jan. PMID 21098140, Free PMC Article
  4. Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Dahan O, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384582, Free PMC Article
  5. Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. Tsai WY, et al. J Biol Chem, 1999 Apr 2. PMID 10092627

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to first spliceosomal transesterification activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ntc20p
NP_009747.3
  • Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    603685..604107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178536.3 → NP_009747.3  TPA: Ntc20p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009747.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQI3, P38302
    UniProtKB/TrEMBL
    A6ZLC9, G2W9J0, N1P9J8
    Conserved Domains (1) summary
    pfam08315
    Location:3 → 127
    cwf18; cwf18 pre-mRNA splicing factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38302.1

Gene LinkOut

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