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MET8 bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852514, updated on 2-Nov-2024

Summary

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Official Symbol
MET8
Official Full Name
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
Primary source
SGD:S000000417
Locus tag
YBR213W
See related
AllianceGenome:SGD:S000000417; FungiDB:YBR213W; VEuPathDB:YBR213W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferrochelatase activity and precorrin-2 dehydrogenase activity. Involved in siroheme biosynthetic process and sulfate assimilation. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MET8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (650368..651192)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ame1p Neighboring gene Ngr1p Neighboring gene Sds24p Neighboring gene Hpc2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Optimization of Met8p crystals through protein-storage buffer manipulation. Schubert HL, et al. Acta Crystallogr D Biol Crystallogr, 2001 Jun. PMID 11375511
  2. The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase. Schubert HL, et al. EMBO J, 2002 May 1. PMID 11980703, Free PMC Article
  3. The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Raux E, et al. Biochem J, 1999 Mar 15. PMID 10051442, Free PMC Article
  4. Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation. Thomas D, et al. J Gen Microbiol, 1992 Oct. PMID 1479340
  5. Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. Baradaran-Heravi A, et al. Nucleic Acids Res, 2016 Aug 19. PMID 27407112, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables precorrin-2 dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables precorrin-2 dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables precorrin-2 dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables sirohydrochlorin ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in siroheme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in siroheme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
NP_009772.1
  • Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    650368..651192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178561.1 → NP_009772.1  TPA: bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK9, P15807
    UniProtKB/TrEMBL
    G2W9L6
    Conserved Domains (1) summary
    COG1648
    Location:2 → 254
    CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15807.1

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