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Slc44a1 solute carrier family 44 member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85254, updated on 17-Aug-2024

Summary

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Official Symbol
Slc44a1provided by RGD
Official Full Name
solute carrier family 44 member 1provided by RGD
Primary source
RGD:621426
See related
EnsemblRapid:ENSRNOG00000055089 AllianceGenome:RGD:621426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ctl1; Cdw92
Summary
Enables choline transmembrane transporter activity. Involved in choline transport and transmembrane transport. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SLC44A1 (solute carrier family 44 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 107.8), Adrenal (RPKM 103.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc44a1 in Genome Data Viewer
Location:
5q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (72857323..73037279)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (68061941..68241912)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (70243643..70424115)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551410 Neighboring gene uncharacterized LOC120102879 Neighboring gene ribosomal protein S23, pseudogene 8 Neighboring gene uncharacterized LOC102551474 Neighboring gene chromobox protein homolog 3-like Neighboring gene fibronectin type III and SPRY domain containing 1-like Neighboring gene fukutin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT. Lee NY, et al. Placenta, 2009 Apr. PMID 19246089
  2. Na(+)-independent choline transport in rat retinal capillary endothelial cells. Tomi M, et al. Neurochem Res, 2007 Nov. PMID 17520363
  3. Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes. Inazu M, et al. J Neurochem, 2005 Sep. PMID 16000150
  4. Changes in mRNA for choline transporter-like protein following facial nerve transection. Che YH, et al. Brain Res Mol Brain Res, 2002 May 30. PMID 12007839
  5. Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. Heffernan C, et al. J Biol Chem, 2017 Mar 17. PMID 28119456, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC44A1 acts as a choline transporter both in the plasma membrane and in the mitochondria. Novel aspects of choline transport regulation in the muscle, nervous system, and cancer are reviewed. Review.
    Title: Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1.
  2. CTL1-deficient Schwann cells are significantly impaired in their ability to myelinate neurites in vitro.
    Title: Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro.
  3. Choline transport via choline transporter-like protein 1 in conditionally immortalized syncytiotrophoblast cell lines TR-TBT.
    Title: Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT.
  4. Although rat CTL1 expression is associated with the choline uptake, CTL1 does not play a major role in the choline uptake at the inner blood-retinal barrier.
    Title: Na(+)-independent choline transport in rat retinal capillary endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables choline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables choline transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables choline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables choline transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ethanolamine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ethanolamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables organic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in choline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in choline transport IEA
Inferred from Electronic Annotation
more info
  
involved_in choline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in choline transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ethanolamine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ethanolamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in ethanolamine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
choline transporter-like protein 1
Names
CDW92 antigen
solute carrier family 44 (choline transporter), member 1
transporter-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033852.1 → NP_001029024.1  choline transporter-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001029024.1

    Status: VALIDATED

    Source sequence(s)
    AJ420809, BM391692, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    UniProtKB/TrEMBL
    A0A0G2K0P8, A6KDP2
    Related
    ENSRNOP00000071535.1, ENSRNOT00000083983.3
    Conserved Domains (1) summary
    pfam04515
    Location:292 → 603
    Choline_transpo; Plasma-membrane choline transporter

  2. NM_053492.4 → NP_445944.2  choline transporter-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_445944.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    UniProtKB/TrEMBL
    A0A0G2K7R8, A6KDP1
    Related
    ENSRNOP00000074317.1, ENSRNOT00000082108.3
    Conserved Domains (1) summary
    pfam04515
    Location:292 → 603
    Choline_transpo; Plasma-membrane choline transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    72857323..73037279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763717.3 → XP_008761939.1  choline transporter-like protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    Conserved Domains (1) summary
    pfam04515
    Location:297 → 608
    Choline_transpo; Plasma-membrane choline transporter

  2. XM_008763716.4 → XP_008761938.1  choline transporter-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    Conserved Domains (1) summary
    pfam04515
    Location:297 → 608
    Choline_transpo; Plasma-membrane choline transporter

  3. XM_039110883.2 → XP_038966811.1  choline transporter-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    Conserved Domains (1) summary
    pfam04515
    Location:298 → 608
    Choline_transpo; Plasma-membrane choline transporter

  4. XM_039110884.2 → XP_038966812.1  choline transporter-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    Conserved Domains (1) summary
    pfam04515
    Location:293 → 603
    Choline_transpo; Plasma-membrane choline transporter

  5. XM_039110885.2 → XP_038966813.1  choline transporter-like protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q8VII6, Q9JJZ7
    Conserved Domains (1) summary
    pfam04515
    Location:256 → 566
    Choline_transpo; Plasma-membrane choline transporter

  6. XM_039110886.2 → XP_038966814.1  choline transporter-like protein 1 isoform X6

    Conserved Domains (1) summary
    pfam04515
    Location:68 → 378
    Choline_transpo; Plasma-membrane choline transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VII6.1 GenPept UniProtKB/Swiss-Prot:Q8VII6

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