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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 852540, updated on 18-Sep-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000000442
Locus tag
YBR238C
See related
AllianceGenome:SGD:S000000442; FungiDB:YBR238C; VEuPathDB:YBR238C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in aerobic respiration. Located in P-body. Is integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (695107..697302, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mRNA (guanine-N7)-methyltransferase Neighboring gene DEAD-box RNA helicase PRP5 Neighboring gene Ert1p Neighboring gene Thi2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rmd9p controls the processing/stability of mitochondrial mRNAs and its overexpression compensates for a partial deficiency of oxa1p in Saccharomyces cerevisiae. Nouet C, et al. Genetics, 2007 Mar. PMID 17194787, Free PMC Article
  2. Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases. Liu Y, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833713, Free PMC Article
  3. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Kaeberlein M, et al. Science, 2005 Nov 18. PMID 16293764
  4. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Delaney JR, et al. Aging Cell, 2011 Dec. PMID 21902802, Free PMC Article
  5. Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Delaney JR, et al. Aging Cell, 2013 Feb. PMID 23167605, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms.
    Title: Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_009797.1
  • Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    695107..697302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178586.1 → NP_009797.1  TPA: uncharacterized protein YBR238C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009797.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQN4, P38330
    UniProtKB/TrEMBL
    A6ZLH7, B3LMS4, C7GMR5, D3UEY6, G2W9P1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38330.1

Gene LinkOut

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