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YBR242W 5'-deoxynucleotidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852544, updated on 7-Jul-2024

Summary

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Gene symbol
YBR242W
Gene description
5'-deoxynucleotidase
Primary source
FungiDB:YBR242W
Locus tag
YBR242W
See related
SGD:S000000446; AllianceGenome:SGD:S000000446; VEuPathDB:YBR242W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 5'-deoxynucleotidase activity and GMP 5'-nucleotidase activity. Involved in deoxyribonucleoside monophosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YBR242W in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (704670..705386)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Thi2p Neighboring gene Vvs1p Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene glutathione peroxidase GPX2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of the yeast HD domain containing protein YGK1 reveals a metal-dependent nucleoside 5'-monophosphatase. Yang J, et al. Biochem Biophys Res Commun, 2018 Jun 27. PMID 29752939
  2. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article
  3. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
  4. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article
  5. An inter-species protein-protein interaction network across vast evolutionary distance. Zhong Q, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107014, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-deoxynucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-deoxynucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables GMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in deoxyribonucleoside monophosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
5'-deoxynucleotidase
NP_009801.1
  • 5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    704670..705386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178590.1 → NP_009801.1  TPA: 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009801.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQN8, P38331
    UniProtKB/TrEMBL
    A0A8H4F810, A6ZLI1, B3LMS0, C7GMY9, D3UEZ0, G2W9P5, N1PAV8
    Conserved Domains (1) summary
    COG1896
    Location:44 → 231
    YfbR; 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38331.1

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