GPX2 glutathione peroxidase GPX2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPX2
Official Full Name: glutathione peroxidase GPX2
Primary source: SGD:S000000448
Locus tag: YBR244W
See related: AllianceGenome:SGD:S000000448; FungiDB:YBR244W; VEuPathDB:YBR244W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AMI1
Summary: Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Is extrinsic component of mitochondrial inner membrane and extrinsic component of mitochondrial outer membrane. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Sedaghatian type and type 2 diabetes mellitus. Orthologous to several human genes including GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GPX2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (707528..708016)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gpx2 was found to exist in the cytoplasm and mitochondria.
Title: Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation.
determination that Gpx2 codes for an atypical 2-Cys peroxiredoxin and is likely to play an important role in the protection of cells from oxidative stress in the presence of Ca2+
Title: GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid-hydroperoxide glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione peroxidase GPX2

NP_009803.3

EC 1.11.1.24

Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

707528..708016

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178592.3 → NP_009803.3 TPA: glutathione peroxidase GPX2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009803.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQP0, P38143

UniProtKB/TrEMBL

A6ZLI3, B3LMR8, C7GMY7, G2W9P7, N1P8J4

Conserved Domains (1) summary

COG0386
Location:1 → 162

BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]