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HIS7 imidazoleglycerol-phosphate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852550, updated on 14-Nov-2024

Summary

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Official Symbol
HIS7
Official Full Name
imidazoleglycerol-phosphate synthase
Primary source
SGD:S000000452
Locus tag
YBR248C
See related
AllianceGenome:SGD:S000000452; FungiDB:YBR248C; VEuPathDB:YBR248C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutaminase activity and imidazoleglycerol-phosphate synthase activity. Involved in L-histidine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HIS7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (714807..716465, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene diphthamide synthase Neighboring gene snoRNA-binding rRNA-processing protein ENP1 Neighboring gene 3-deoxy-7-phosphoheptulonate synthase ARO4 Neighboring gene Spo23p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insight into gene fusion from molecular dynamics simulation of fused and un-fused IGPS (Imidazole Glycerol Phosphate Synthetase). Yiting Y, et al. Bioinformation, 2006 Feb 28. PMID 17611615, Free PMC Article
  2. The adjacent yeast genes ARO4 and HIS7 carry no intergenic region. Springer C, et al. J Biol Chem, 1997 Oct 17. PMID 9334203
  3. A network of conserved interactions regulates the allosteric signal in a glutamine amidotransferase. Amaro RE, et al. Biochemistry, 2007 Feb 27. PMID 17261030
  4. Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase. Myers RS, et al. Biochemistry, 2003 Jun 17. PMID 12795596
  5. Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites. Chaudhuri BN, et al. Structure, 2001 Oct. PMID 11591353

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables imidazoleglycerol-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables imidazoleglycerol-phosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables imidazoleglycerol-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
imidazoleglycerol-phosphate synthase
NP_009807.3
  • Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    714807..716465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178596.3 → NP_009807.3  TPA: imidazoleglycerol-phosphate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009807.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQP4, P33734
    UniProtKB/TrEMBL
    B3LMR4, C7GMY3, D3UEZ5, G2W9Q1, N1P9M2
    Conserved Domains (1) summary
    PLN02617
    Location:2 → 549
    PLN02617; imidazole glycerol phosphate synthase hisHF
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33734.2

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