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ARO4 3-deoxy-7-phosphoheptulonate synthase ARO4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852551, updated on 28-Oct-2024

Summary

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Official Symbol
ARO4
Official Full Name
3-deoxy-7-phosphoheptulonate synthase ARO4
Primary source
SGD:S000000453
Locus tag
YBR249C
See related
AllianceGenome:SGD:S000000453; FungiDB:YBR249C; VEuPathDB:YBR249C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-deoxy-7-phosphoheptulonate synthase activity. Predicted to be involved in aromatic amino acid family biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ARO4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (716882..717994, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein ENP1 Neighboring gene imidazoleglycerol-phosphate synthase Neighboring gene Spo23p Neighboring gene mitochondrial 37S ribosomal protein MRPS5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism. König V, et al. J Mol Biol, 2004 Mar 26. PMID 15019786
  2. A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae. Fukuda K, et al. Curr Genet, 1991 Dec. PMID 1723662
  3. The two 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isoenzymes from Saccharomyces cerevisiae show different kinetic modes of inhibition. Schnappauf G, et al. Arch Microbiol, 1998 Jun. PMID 9575238
  4. Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast. Meuris P. Genetics, 1974 Apr. PMID 4599255, Free PMC Article
  5. Genetic transformation of industrial yeasts using an amino acid analog resistance gene as a directly selectable marker. Shimura K, et al. Enzyme Microb Technol, 1993 Oct. PMID 7764106

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
3-deoxy-7-phosphoheptulonate synthase ARO4
NP_009808.1
  • 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    716882..717994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178597.1 → NP_009808.1  TPA: 3-deoxy-7-phosphoheptulonate synthase ARO4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009808.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQP5, P32449
    UniProtKB/TrEMBL
    A6ZLI8, B3LMR3, B5VEJ9, C7GMY2, D3UEZ6, G2W9Q2, N1P8J9
    Conserved Domains (1) summary
    TIGR00034
    Location:21 → 365
    aroFGH; phospho-2-dehydro-3-deoxyheptonate aldolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32449.2

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