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MIC12 Mic12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852566, updated on 29-Jun-2024

Summary

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Gene symbol
MIC12
Gene description
Mic12p
Primary source
FungiDB:YBR262C
Locus tag
YBR262C
See related
SGD:S000000466; AllianceGenome:SGD:S000000466; VEuPathDB:YBR262C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM5; FMP51; MCS12
Summary
Involved in cellular protein-containing complex assembly and cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MIC12 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (735720..736040, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RGD1 Neighboring gene N-terminal protein methyltransferase Neighboring gene glycine hydroxymethyltransferase SHM1 Neighboring gene Rab family GTPase YPT10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Stoldt S, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028145, Free PMC Article
  2. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
  3. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
  4. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article
  5. Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase. Dietz JV, et al. Redox Biol, 2021 Oct. PMID 34517185, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in addition to the MICOS core components Mic10 and Mic60, Mic12 and Mic27 play specific roles in the organization of the MICOS complex
    Title: Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cristae formation IEA
Inferred from Electronic Annotation
more info
  
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial crista junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial crista junction IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mic12p
NP_009821.3
  • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    735720..736040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178610.3 → NP_009821.3  TPA: Mic12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009821.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZLK2, B3LMP9, C7GMW8, D3UF10, D6VQQ9, P38341
    UniProtKB/TrEMBL
    A0A6A5Q5L3, G2W9R7, N1P9M8
    Conserved Domains (1) summary
    pfam17050
    Location:79 → 102
    AIM5; Altered inheritance of mitochondria 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38341.1

Gene LinkOut

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