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Cnga4 cyclic nucleotide gated channel subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85258, updated on 10-Jul-2024

Summary

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Official Symbol
Cnga4provided by RGD
Official Full Name
cyclic nucleotide gated channel subunit alpha 4provided by RGD
Primary source
RGD:619844
See related
EnsemblRapid:ENSRNOG00000017609 AllianceGenome:RGD:619844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CNG4; CNG5; Cgn2; CNG-4; OCNC2; rOCNC2
Summary
Enables cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in cation transmembrane transport. Predicted to act upstream of or within sensory perception of smell. Located in perikaryon and plasma membrane. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 11.3), Heart (RPKM 1.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Cnga4 in Genome Data Viewer
Location:
1q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169134332..169168317)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159752357..159756369)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170238959..170246858)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene similar to human chromosome 11 open reading frame 42 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene uncharacterized LOC108349007 Neighboring gene cholecystokinin B receptor Neighboring gene caveolae associated protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Liman ER, et al. Neuron, 1994 Sep. PMID 7522482
  2. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Bradley J, et al. Proc Natl Acad Sci U S A, 1994 Sep 13. PMID 7522325, Free PMC Article
  3. Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Nache V, et al. Sci Signal, 2012 Jul 10. PMID 22786723
  4. Localization of olfactory cyclic nucleotide-gated channels in rat gonadotropin-releasing hormone neurons. El-Majdoubi M, et al. Endocrinology, 2002 Jun. PMID 12021210
  5. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Munger SD, et al. Science, 2001 Dec 7. PMID 11739959, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cGMP activated olfactory CNG channels by binding to the two CNGA2 subunits and the CNGA4 subunit.
    Title: Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cGMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cAMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cGMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intracellular cyclic nucleotide activated cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated cation channel alpha-4
Names
CNCalpha4 C
CNG channel alpha-4
cyclic nucleotide gated cation channel
cyclic nucleotide gated channel alpha 4
cyclic nucleotide-gated olfactory channel subunit OCNC2
olfactory cyclic nucleotide-gated channel
olfactory cyclic nucleotide-gated channel subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053496.2 → NP_445948.2  cyclic nucleotide-gated channel alpha-4

    See identical proteins and their annotated locations for NP_445948.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001, U12623
    UniProtKB/Swiss-Prot
    Q64359, Q6Q2I4
    UniProtKB/TrEMBL
    A6I7I1, G3V898
    Related
    ENSRNOP00000023751.4, ENSRNOT00000023751.9
    Conserved Domains (5) summary
    COG0664
    Location:342 → 519
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:348 → 464
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:58 → 273
    Ion_trans; Ion transport protein
    pfam16526
    Location:464 → 535
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    cl21455
    Location:116 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    169134332..169168317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275896.1 → XP_063131966.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

  2. XM_063275897.1 → XP_063131967.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

  3. XM_063275895.1 → XP_063131965.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

  4. XM_063275898.1 → XP_063131968.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64359.1 GenPept UniProtKB/Swiss-Prot:Q64359

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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