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SSH1 Ssh1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852586, updated on 28-Oct-2024

Summary

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Official Symbol
SSH1
Official Full Name
Ssh1p
Primary source
SGD:S000000487
Locus tag
YBR283C
See related
AllianceGenome:SGD:S000000487; FungiDB:YBR283C; VEuPathDB:YBR283C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables signal sequence binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in endoplasmic reticulum. Part of Ssh1 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See SSH1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (768943..770415, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase subunit DUG2 Neighboring gene mitochondrial 54S ribosomal protein YmL27 Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene Hab1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Holmstrøm K, et al. Yeast, 1994 Apr. PMID 8091861
  2. The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration. Junne T, et al. Mol Biol Cell, 2010 May 15. PMID 20357000, Free PMC Article
  3. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Jan CH, et al. Science, 2014 Nov 7. PMID 25378630, Free PMC Article
  4. Mutations in the Sec61p channel affecting signal sequence recognition and membrane protein topology. Junne T, et al. J Biol Chem, 2007 Nov 9. PMID 17893139
  5. Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation. Cheng Z, et al. J Cell Biol, 2005 Jan 3. PMID 15631991, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ssh1 translocon complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ssh1p
NP_009842.1
  • Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    768943..770415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178631.1 → NP_009842.1  TPA: Ssh1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009842.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQS8, P38353
    UniProtKB/TrEMBL
    A6ZLM1, B3LMN0, C7GMU9, D3UF30, G2W9T6, N1P8N7
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 472
    PTZ00219; Sec61 alpha subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38353.1

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