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BSD2 Bsd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852593, updated on 2-Nov-2024

Summary

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Official Symbol
BSD2
Official Full Name
Bsd2p
Primary source
SGD:S000000494
Locus tag
YBR290W
See related
AllianceGenome:SGD:S000000494; FungiDB:YBR290W; VEuPathDB:YBR290W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in metal ion transport; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum and fungal-type vacuole membrane. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1) and NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BSD2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (782591..783556)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Apm3p Neighboring gene Snf5p Neighboring gene Ctp1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel role for Bsd2 in the resistance of yeast to adriamycin. Takahashi T, et al. J Cell Physiol, 2005 Jan. PMID 15389553
  2. The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene. Liu XF, et al. Mol Cell Biol, 1994 Nov. PMID 7935419, Free PMC Article
  3. Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene. Liu XF, et al. J Biol Chem, 1999 Feb 19. PMID 9988727
  4. Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Yu D, et al. Bioinformatics, 2011 Aug 15. PMID 21685046, Free PMC Article
  5. The yeast BSD2-1 mutation influences both the requirement for phosphatidylinositol transfer protein function and derepression of phospholipid biosynthetic gene expression in yeast. Kagiwada S, et al. Genetics, 1996 Jun. PMID 8725219, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the resistance to adriamycin acquired by overexpression of BSD2 might be partially explained by down-regulation of Smf2
    Title: A novel role for Bsd2 in the resistance of yeast to adriamycin.
  2. Bsd2 provides an alternative ubiquitination mechanism for Cps1, Phm5 and other proteins
    Title: Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in metal ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bsd2p
NP_009849.1
  • Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    782591..783556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178638.1 → NP_009849.1  TPA: Bsd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQT5, P38356
    UniProtKB/TrEMBL
    A6ZLM8, B3LMM3, B5VEN4, C7GMU2, D3UF37, G2W9U3, N1P8X2
    Conserved Domains (1) summary
    pfam10176
    Location:106 → 319
    DUF2370; Protein of unknown function (DUF2370)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38356.1

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