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MTO1 tRNA modification protein MTO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852616, updated on 9-Jun-2024

Summary

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Gene symbol
MTO1
Gene description
tRNA modification protein MTO1
Primary source
FungiDB:YGL236C
Locus tag
YGL236C
See related
SGD:S000003205; AllianceGenome:SGD:S000003205; VEuPathDB:YGL236C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
IPS1
Summary
Predicted to enable flavin adenine dinucleotide binding activity. Involved in mitochondrial tRNA wobble uridine modification. Located in mitochondrion. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MTO1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (53787..55796, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene importin-alpha export receptor Neighboring gene transcription activator HAP2 Neighboring gene uncharacterized protein Neighboring gene bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase Neighboring gene Rab GTPase-binding exocyst subunit SEC15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutation. Zhu X, et al. PLoS One, 2015. PMID 25898254, Free PMC Article
  2. Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis. Ghezzi D, et al. Am J Hum Genet, 2012 Jun 8. PMID 22608499, Free PMC Article
  3. Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. Wang X, et al. Mitochondrion, 2009 Jun. PMID 19460296, Free PMC Article
  4. MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. Colby G, et al. J Biol Chem, 1998 Oct 23. PMID 9774408
  5. Identification and characterization of mouse MTO1 gene related to mitochondrial tRNA modification. Li R, et al. Biochim Biophys Acta, 2003 Oct 1. PMID 14522080

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The deletion of the nuclear gene MTO1 regulates neomycin sensitivity in yeast carrying the mitochondrial 15S rRNA C1477G mutation.
    Title: MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutation.
  2. The respiratory yeast phenotype for MTO1 was dramatically worsened in stress conditions and in the presence of a paromomycin-resistant (P(R)) mitochondrial rRNA mutation
    Title: Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.
  3. These data strongly indicate that unmodified tRNA caused by the deletion of MTO1 gene caused the instability of mitochondrial tRNAs and mRNAs and an impairment of aminoacylation of mitochondrial tRNAs.
    Title: Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA modification protein MTO1
NP_011278.2
  • Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    53787..55796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181102.1 → NP_011278.2  TPA: tRNA modification protein MTO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011278.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV98, P53070
    UniProtKB/TrEMBL
    A0A8H4BZW5, A6ZTV4, B3LHS9, B5VIA7, C7GNY3, C8Z819
    Conserved Domains (1) summary
    TIGR00136
    Location:37 → 665
    gidA; glucose-inhibited division protein A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53070.2

Gene LinkOut

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