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VID30 glucose-induced degradation complex subunit VID30 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852624, updated on 18-Sep-2024

Summary

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Official Symbol
VID30
Official Full Name
glucose-induced degradation complex subunit VID30
Primary source
SGD:S000003196
Locus tag
YGL227W
See related
AllianceGenome:SGD:S000003196; FungiDB:YGL227W; VEuPathDB:YGL227W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GID1
Summary
Involved in negative regulation of gluconeogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of nitrogen utilization. Located in cytoplasm and nucleus. Part of GID complex. Orthologous to human RANBP10 (RAN binding protein 10) and RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VID30 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (69671..72547)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sap4p Neighboring gene She10p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit Neighboring gene Mtc3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism. Eder M, et al. Sci Rep, 2020 Feb 7. PMID 32034164, Free PMC Article
  2. Vid30 is required for the association of Vid vesicles and actin patches in the vacuole import and degradation pathway. Alibhoy AA, et al. Autophagy, 2012 Jan. PMID 22082961, Free PMC Article
  3. Isolation of degradation-deficient mutants defective in the targeting of fructose-1,6-bisphosphatase into the vacuole for degradation in Saccharomyces cerevisiae. Hoffman M, et al. Genetics, 1996 Aug. PMID 8844145, Free PMC Article
  4. Proteins of newly isolated mutants and the amino-terminal proline are essential for ubiquitin-proteasome-catalyzed catabolite degradation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. Hämmerle M, et al. J Biol Chem, 1998 Sep 25. PMID 9737955
  5. Vid28 protein is required for the association of vacuole import and degradation (Vid) vesicles with actin patches and the retention of Vid vesicle proteins in the intracellular fraction. Giardina BJ, et al. J Biol Chem, 2013 Apr 26. PMID 23393132, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
    Title: QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
  2. turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
    Title: Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
  3. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
    Title: Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-induced degradation complex subunit VID30
NP_011287.1
  • Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    69671..72547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181093.1 → NP_011287.1  TPA: glucose-induced degradation complex subunit VID30 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011287.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVA7, P53076
    UniProtKB/TrEMBL
    A6ZTW3, B3LHS0, B5VIB4, C7GNX4
    Conserved Domains (3) summary
    smart00668
    Location:769 → 826
    CTLH; C-terminal to LisH motif
    smart00757
    Location:828 → 935
    CRA; CT11-RanBPM
    cd12885
    Location:386 → 588
    SPRY_RanBP_like; SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53076.1

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