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Slc25a14 solute carrier family 25 member 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85263, updated on 2-Nov-2024

Summary

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Official Symbol
Slc25a14provided by RGD
Official Full Name
solute carrier family 25 member 14provided by RGD
Primary source
RGD:621433
See related
EnsemblRapid:ENSRNOG00000006871 AllianceGenome:RGD:621433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bmcp1
Summary
Predicted to enable inorganic anion transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Predicted to be involved in inorganic anion transport and regulation of cellular response to oxidative stress. Predicted to be located in mitochondrial envelope. Orthologous to human SLC25A14 (solute carrier family 25 member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 63.4), Thymus (RPKM 30.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a14 in Genome Data Viewer
Location:
Xq36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132685518..132723705)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127807630..127845823)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135470855..135509223)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene apoptosis inducing factor, mitochondria associated 1 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C Neighboring gene G protein-coupled receptor 119 Neighboring gene RNA binding motif protein, X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression. Mortensen OH, et al. J Cereb Blood Flow Metab, 2014 Jul. PMID 24756078, Free PMC Article
  2. Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA and its up-regulation during postnatal development. Kondou S, et al. Biochim Biophys Acta, 2000 Apr 21. PMID 10773163
  3. Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. Yamada H, et al. FASEB J, 2019 Oct. PMID 31314594
  4. Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress. Guevara R, et al. Free Radic Biol Med, 2009 Jan 15. PMID 18992805
  5. Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Mizuno T, et al. Biochem Biophys Res Commun, 2000 Nov 30. PMID 11095970

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specificity protein 1 binding to the Ucp5 promoter regions was reduced by DNA methylation.
    Title: Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi.
  2. maternal high-fructose diet during gestation and lactation has long-term effects (fetal programming) on brain mitochondrial function in aging rats, which appears to be linked to an increase in UCP5 protein levels.
    Title: Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression.
  3. expression levels are higher in aged female brain as compared to male one
    Title: Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in inorganic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brain mitochondrial carrier protein 1
Names
solute carrier family 25 (mitochondrial carrier, brain), member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053501.3 → NP_445953.1  brain mitochondrial carrier protein 1 precursor

    See identical proteins and their annotated locations for NP_445953.1

    Status: VALIDATED

    Source sequence(s)
    AF300424, JAXUCZ010000021
    UniProtKB/TrEMBL
    Q791E0, Q9EP88
    Related
    ENSRNOP00000009637.6, ENSRNOT00000009637.7
    Conserved Domains (2) summary
    PTZ00169
    Location:44 → 323
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:234 → 323
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    132685518..132723705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257531.5 → XP_006257593.1  brain mitochondrial carrier protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A296
    Related
    ENSRNOP00000086458.1, ENSRNOT00000095690.2
    Conserved Domains (2) summary
    PTZ00169
    Location:63 → 342
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:253 → 342
    Mito_carr; Mitochondrial carrier protein

  2. XM_006257532.4 → XP_006257594.1  brain mitochondrial carrier protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006257594.1

    UniProtKB/TrEMBL
    Q9JMH0
    Conserved Domains (2) summary
    PTZ00169
    Location:41 → 320
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:231 → 320
    Mito_carr; Mitochondrial carrier protein

  3. XM_006257535.3 → XP_006257597.1  brain mitochondrial carrier protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006257597.1

    Conserved Domains (2) summary
    PTZ00169
    Location:9 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:199 → 288
    Mito_carr; Mitochondrial carrier protein

  4. XM_008773531.4 → XP_008771753.1  brain mitochondrial carrier protein 1 isoform X3

    See identical proteins and their annotated locations for XP_008771753.1

    Related
    ENSRNOP00000107630.1, ENSRNOT00000130127.1
    Conserved Domains (2) summary
    PTZ00169
    Location:9 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:199 → 288
    Mito_carr; Mitochondrial carrier protein

  5. XM_039100123.2 → XP_038956051.1  brain mitochondrial carrier protein 1 isoform X3

    Conserved Domains (2) summary
    PTZ00169
    Location:9 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:199 → 288
    Mito_carr; Mitochondrial carrier protein

  6. XM_039100125.2 → XP_038956053.1  brain mitochondrial carrier protein 1 isoform X5

    Conserved Domains (1) summary
    pfam00153
    Location:90 → 179
    Mito_carr; Mitochondrial carrier protein

  7. XM_039100124.2 → XP_038956052.1  brain mitochondrial carrier protein 1 isoform X4

RNA

  1. XR_010061260.1 RNA Sequence

  2. XR_005498077.2 RNA Sequence

  3. XR_005498078.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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