FZF1 Fzf1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FZF1
Official Full Name: Fzf1p
Primary source: SGD:S000003223
Locus tag: YGL254W
See related: AllianceGenome:SGD:S000003223; FungiDB:YGL254W; VEuPathDB:YGL254W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NRC299; RSU1; SUL1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FZF1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (22304..23203)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cysteine residues in the fourth zinc finger are important for activation of the nitric oxide-inducible transcription factor Fzf1 in the yeast Saccharomyces cerevisiae.
Title: Cysteine residues in the fourth zinc finger are important for activation of the nitric oxide-inducible transcription factor Fzf1 in the yeast Saccharomyces cerevisiae.
Chimeric alleles from four Saccharomyces species show that divergence in FZF1 activity is due to changes in both its coding and upstream noncoding sequence.
Title: Divergence of the yeast transcription factor FZF1 affects sulfite resistance.
The presence of *NO or *NO derivatives activates Fzf1p leading to transcriptional induction of a discrete set of target genes that function to protect the cell from *NO-mediated stress.
Title: Fzf1p regulates an inducible response to nitrosative stress in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cyanamide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sulfite transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Fzf1p

NP_011260.1

Transcription factor involved in sulfite metabolism; activates transcription of SSU1, DDI2, DDI3; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

22304..23203

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181120.1 → NP_011260.1 TPA: Fzf1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011260.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV81, P32805, Q2VQB9, Q2VQC2, Q2VQC3

UniProtKB/TrEMBL

D0UZV3

Conserved Domains (2) summary

COG5048
Location:15 → 297

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:17 → 36

ZF_C2H2; C2H2 Zn finger [structural motif]