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ZIP2 Zip2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852643, updated on 2-Nov-2024

Summary

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Official Symbol
ZIP2
Official Full Name
Zip2p
Primary source
SGD:S000003218
Locus tag
YGL249W
See related
AllianceGenome:SGD:S000003218; FungiDB:YGL249W; VEuPathDB:YGL249W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA secondary structure binding activity. Involved in positive regulation of protein sumoylation; reciprocal meiotic recombination; and synaptonemal complex assembly. Located in synaptonemal complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZIP2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (33098..35212)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene DNA helicase Neighboring gene Rmr1p Neighboring gene ncRNA Neighboring gene 3',5'-cyclic-nucleotide phosphodiesterase PDE1 Neighboring gene Brr6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis. Chua PR, et al. Cell, 1998 May 1. PMID 9590170
  2. Initiation of meiotic chromosome synapsis at centromeres in budding yeast. Tsubouchi T, et al. Genes Dev, 2008 Nov 15. PMID 19056898, Free PMC Article
  3. Global analysis of the meiotic crossover landscape. Chen SY, et al. Dev Cell, 2008 Sep. PMID 18691940, Free PMC Article
  4. The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2. Tsubouchi T, et al. Dev Cell, 2006 Jun. PMID 16740482
  5. The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Novak JE, et al. Genetics, 2001 Jul. PMID 11454751, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ur data support a model in which the Zip2:Zip4:Spo16 complex binds and stabilizes early meiotic recombination intermediates, then coordinates additional factors to promote crossover formation and license downstream events including synaptonemal complex assembly.
    Title: The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding.
  2. Identification of the ZZS (Zip2-Zip4-Spo16) complex which is required for crossover formation.
    Title: A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
  3. Spo22 (also called Zip4) is identified as a probable functional collaborator of Zip2/3
    Title: Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA secondary structure binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Zip2p
NP_011265.1
  • Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    33098..35212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181115.1 → NP_011265.1  TPA: Zip2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV86, P53061
    UniProtKB/TrEMBL
    B3LHU1, C8Z809
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53061.1

Gene LinkOut

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