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Slc24a3 solute carrier family 24 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85267, updated on 2-Nov-2024

Summary

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Official Symbol
Slc24a3provided by RGD
Official Full Name
solute carrier family 24 member 3provided by RGD
Primary source
RGD:69256
See related
EnsemblRapid:ENSRNOG00000060687 AllianceGenome:RGD:69256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nckx3
Summary
Enables calcium, potassium:sodium antiporter activity. Involved in monoatomic cation transport. Located in cell periphery. Orthologous to human SLC24A3 (solute carrier family 24 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 118.8), Uterus (RPKM 103.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc24a3 in Genome Data Viewer
Location:
3q41
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (153005418..153504497)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (132552119..133051192)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (139333942..139835728)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486167 Neighboring gene D-aminoacyl-tRNA deacylase 1 Neighboring gene SCP2 sterol-binding domain containing 1 Neighboring gene uncharacterized LOC120101723 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350484 Neighboring gene U4 spliceosomal RNA Neighboring gene Ras and Rab interactor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats. Yang H, et al. Mol Reprod Dev, 2010 Nov. PMID 21104767
  2. NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Yang H, et al. Mol Cell Endocrinol, 2017 Oct 15. PMID 28602864
  3. K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney. Lee GS, et al. Am J Physiol Renal Physiol, 2009 Aug. PMID 19474185
  4. Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle. Yang H, et al. Biochem Biophys Res Commun, 2009 Jul 24. PMID 19464262
  5. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Dong H, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16617138

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NCKX3 may be involved in reproductive function during the estrous cycle in female rats.
    Title: Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats.
  2. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
    Title: Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
  3. mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle providing evidence for their role in mediating vascular tone.
    Title: Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium, potassium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium, potassium:sodium antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium, potassium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium, potassium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/potassium/calcium exchanger 3
Names
Na(+)/K(+)/Ca(2+)-exchange protein 3
potassium-dependent sodium-calcium exchanger NCKX3 (SLC24A3)
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053505.3 → NP_445957.2  sodium/potassium/calcium exchanger 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9EPQ0
    Related
    ENSRNOP00000093366.1, ENSRNOT00000115668.2
    Conserved Domains (2) summary
    TIGR00367
    Location:111 → 604
    TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
    pfam01699
    Location:112 → 254
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    153005418..153504497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106001.2 → XP_038961929.1  sodium/potassium/calcium exchanger 3 isoform X2

    UniProtKB/Swiss-Prot
    Q9EPQ0
    UniProtKB/TrEMBL
    A6K770
    Related
    ENSRNOP00000071351.2, ENSRNOT00000089098.3
    Conserved Domains (1) summary
    TIGR00927
    Location:39 → 578
    2A1904; K+-dependent Na+/Ca+ exchanger

  2. XM_063284741.1 → XP_063140811.1  sodium/potassium/calcium exchanger 3 isoform X1

    Related
    ENSRNOP00000110531.1, ENSRNOT00000158472.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPQ0.1 GenPept UniProtKB/Swiss-Prot:Q9EPQ0

Gene LinkOut

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