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SUT1 Sut1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852714, updated on 2-Nov-2024

Summary

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Official Symbol
SUT1
Official Full Name
Sut1p
Primary source
SGD:S000003130
Locus tag
YGL162W
See related
AllianceGenome:SGD:S000003130; FungiDB:YGL162W; VEuPathDB:YGL162W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including positive regulation of induction of conjugation with cellular fusion; positive regulation of sterol import; and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SUT1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (198138..199037)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Yrb30p Neighboring gene DNA-dependent ATPase RAD54 Neighboring gene Yip5p Neighboring gene putative metalloreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Bourot S, et al. Gene, 1995 Nov 7. PMID 7489925
  2. SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Ness F, et al. Eur J Biochem, 2001 Mar. PMID 11248676
  3. SUT1 suppresses sec14-1 through upregulation of CSR1 in Saccharomyces cerevisiae. Régnacq M, et al. FEMS Microbiol Lett, 2002 Nov 5. PMID 12435498
  4. Predictive models of eukaryotic transcriptional regulation reveals changes in transcription factor roles and promoter usage between metabolic conditions. Holland P, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30976803, Free PMC Article
  5. SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Alimardani P, et al. Biochem J, 2004 Jul 1. PMID 15035656, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of filamentous growth of a population of unicellular organisms IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of induction of conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of sterol import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sut1p
NP_011353.1
  • Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    198138..199037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181027.1 → NP_011353.1  TPA: Sut1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTY9, P53032
    UniProtKB/TrEMBL
    C7GPP4, C8Z889, G2WDU2, N1PA08
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53032.1

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