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ARI1 carbonyl reductase (NADPH-dependent) ARI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852720, updated on 2-Nov-2024

Summary

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Official Symbol
ARI1
Official Full Name
carbonyl reductase (NADPH-dependent) ARI1
Primary source
SGD:S000003125
Locus tag
YGL157W
See related
AllianceGenome:SGD:S000003125; FungiDB:YGL157W; VEuPathDB:YGL157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carbonyl reductase (NADPH) activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARI1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (209006..210049)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene putative serine/threonine protein kinase RCK1 Neighboring gene alpha-mannosidase Neighboring gene protein geranylgeranyltransferase type I subunit CDC43

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stereochemistry of furfural reduction by a Saccharomyces cerevisiae aldehyde reductase that contributes to in situ furfural detoxification. Bowman MJ, et al. Appl Environ Microbiol, 2010 Aug. PMID 20525870, Free PMC Article
  2. Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural. Jordan DB, et al. Biochim Biophys Acta, 2011 Dec. PMID 21890004
  3. Short-chain dehydrogenases/reductases (SDRs). Kallberg Y, et al. Eur J Biochem, 2002 Sep. PMID 12230552
  4. Studying NAD(P)H cofactor-binding to alcohol dehydrogenases through global analysis of circular dichroism spectra. Marolt M , et al. Phys Chem Chem Phys, 2019 Jan 23. PMID 30328850
  5. Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae. Katz M, et al. Biotechnol Bioeng, 2003 Dec 5. PMID 14574691

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural.
    Title: Kinetic mechanism of an aldehyde reductase of Saccharomyces cerevisiae that relieves toxicity of furfural and 5-hydroxymethylfurfural.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbonyl reductase (NADPH-dependent) ARI1
NP_011358.3
  • NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    209006..210049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181022.3 → NP_011358.3  TPA: carbonyl reductase (NADPH-dependent) ARI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011358.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTZ4, P53111
    UniProtKB/TrEMBL
    B3LHL0, C7GPP9, N1P4P9
    Conserved Domains (1) summary
    cd05227
    Location:6 → 323
    AR_SDR_e; aldehyde reductase, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53111.1

Gene LinkOut

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