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ARO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852729, updated on 22-Aug-2024

Summary

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Official Symbol
ARO2
Primary source
FungiDB:YGL148W
Locus tag
YGL148W
See related
SGD:S000003116; AllianceGenome:SGD:S000003116; VEuPathDB:YGL148W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chorismate synthase activity and riboflavin reductase (NADPH) activity. Involved in aromatic amino acid family biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (226399..227529)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nut1p Neighboring gene chromatin-remodeling ATPase INO80 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L9A Neighboring gene Rrt6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae. Quevillon-Cheruel S, et al. J Biol Chem, 2004 Jan 2. PMID 14573601
  2. Saccharomyces cerevisiae chorismate synthase has a flavin reductase activity. Henstrand JM, et al. Mol Microbiol, 1996 Dec. PMID 8971708
  3. Molecular cloning, characterization and analysis of the regulation of the ARO2 gene, encoding chorismate synthase, of Saccharomyces cerevisiae. Jones DG, et al. Mol Microbiol, 1991 Sep. PMID 1837329
  4. Effect of mutation in the aromatic amino acid pathway on sporulation of Saccharomyces cerevisiae. Lucchini G, et al. J Bacteriol, 1978 Oct. PMID 361708, Free PMC Article
  5. The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans. Chaillot J, et al. Antimicrob Agents Chemother, 2015 Aug. PMID 26014932, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables chorismate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chorismate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chorismate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables chorismate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables riboflavin reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chorismate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
NP_011367.1
  • Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    226399..227529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181013.1 → NP_011367.1  TPA: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011367.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU01, P28777
    UniProtKB/TrEMBL
    A6ZU35, B3LHK3, B5VII2, C7GPQ5, C8Z8A2, G2WDV5, N1P2X6
    Conserved Domains (1) summary
    TIGR00033
    Location:8 → 369
    aroC; chorismate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28777.1

Gene LinkOut

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