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ROG1 putative lipase ROG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852733, updated on 2-Nov-2024

Summary

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Official Symbol
ROG1
Official Full Name
putative lipase ROG1
Primary source
SGD:S000003112
Locus tag
YGL144C
See related
AllianceGenome:SGD:S000003112; FungiDB:YGL144C; VEuPathDB:YGL144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables monoacylglycerol lipase activity. Involved in cellular lipid metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ROG1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (232450..234507, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rrt6p Neighboring gene Tip20p Neighboring gene Mrf1p Neighboring gene putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. Vishnu Varthini L, et al. FEBS Lett, 2015 Jan 2. PMID 25433290
  2. Systematic analysis of yeast strains with possible defects in lipid metabolism. Daum G, et al. Yeast, 1999 May. PMID 10341423
  3. Disruption of six novel ORFs from Saccharomyces cerevisiae chromosome VII and phenotypic analysis of the deletants. Victoria Escribano M, et al. Yeast, 2000 May. PMID 10806424
  4. The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames. Voet M, et al. Yeast, 1997 Feb. PMID 9046099
  5. Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Andoh T, et al. Mol Cell Biol, 2000 Sep. PMID 10958669, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Rog1p is a MAG lipase that regulates lipid homeostasis.
    Title: ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative lipase ROG1
NP_011371.1
  • Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    232450..234507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181009.1 → NP_011371.1  TPA: putative lipase ROG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011371.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU05, P53118, Q66RA3
    UniProtKB/TrEMBL
    B3LHJ9, C7GPQ9, C8Z8A6, N1P587
    Conserved Domains (1) summary
    pfam05057
    Location:184 → 382
    DUF676; Putative serine esterase (DUF676)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53118.1

Gene LinkOut

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