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MRM2 21S rRNA (uridine2791-2'-O) methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852741, updated on 18-Sep-2024

Summary

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Official Symbol
MRM2
Official Full Name
21S rRNA (uridine2791-2'-O) methyltransferase
Primary source
SGD:S000003104
Locus tag
YGL136C
See related
AllianceGenome:SGD:S000003104; FungiDB:YGL136C; VEuPathDB:YGL136C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA (uridine-2'-O-)-methyltransferase activity. Involved in rRNA methylation. Located in mitochondrion. Used to study MELAS syndrome. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MRM2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (252897..253859, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene coatomer subunit beta' Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Pcl10p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. Pintard L, et al. EMBO J, 2002 Mar 1. PMID 11867542, Free PMC Article
  2. Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome. Garone C, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973171, Free PMC Article
  3. The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Datta K, et al. Mol Biol Cell, 2005 Feb. PMID 15591131, Free PMC Article
  4. Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Bonnerot C, et al. Mol Cell, 2003 Nov. PMID 14636587
  5. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. Pintard L, et al. EMBO J, 2002 Apr 2. PMID 11927565, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (uridine-2'-O-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
21S rRNA (uridine2791-2'-O) methyltransferase
NP_011379.1
  • Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    252897..253859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181001.1 → NP_011379.1  TPA: 21S rRNA (uridine2791-2'-O) methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011379.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU13, P53123
    UniProtKB/TrEMBL
    A6ZU47, B3LHJ4, C7GPR6, C8Z8B4, G2WDW7, N1P3D6
    Conserved Domains (1) summary
    COG0293
    Location:25 → 310
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53123.1

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