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PCL10 Pcl10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852743, updated on 17-May-2024

Summary

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Gene symbol
PCL10
Gene description
Pcl10p
Primary source
FungiDB:YGL134W
Locus tag
YGL134W
See related
SGD:S000003102; AllianceGenome:SGD:S000003102; VEuPathDB:YGL134W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in negative regulation of glycogen biosynthetic process and regulation of cyclin-dependent protein serine/threonine kinase activity. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PCL10 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (255663..256964)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 21S rRNA (uridine2791-2'-O) methyltransferase Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Itc1p Neighboring gene DNA-binding E3 ubiquitin-protein ligase SNT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition. Zheng F, et al. J Biol Chem, 2013 Oct 18. PMID 24022486, Free PMC Article
  2. Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p. Wilson WA, et al. FEBS Lett, 2002 Mar 27. PMID 11943203
  3. Disruption of six novel ORFs from Saccharomyces cerevisiae chromosome VII and phenotypic analysis of the deletants. Victoria Escribano M, et al. Yeast, 2000 May. PMID 10806424
  4. Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p. Wilson WA, et al. Mol Cell Biol, 1999 Oct. PMID 10490639, Free PMC Article
  5. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. Tan YS, et al. J Biol Chem, 2003 Jan 3. PMID 12407105

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pcl10p
NP_011381.1
  • Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    255663..256964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180999.1 → NP_011381.1  TPA: Pcl10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011381.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU15, P53124
    UniProtKB/TrEMBL
    A0A8H4C1W4, B3LHJ2, B5VIJ7, C7GX67, N1P2Z4
    Conserved Domains (1) summary
    cd20558
    Location:306 → 412
    CYCLIN_ScPCL7-like; cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53124.1

Gene LinkOut

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