U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MLC1 Mlc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852772, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
MLC1
Official Full Name
Mlc1p
Primary source
SGD:S000003074
Locus tag
YGL106W
See related
AllianceGenome:SGD:S000003074; FungiDB:YGL106W; VEuPathDB:YGL106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables myosin II heavy chain binding activity and myosin V binding activity. Involved in protein localization to cell division site involved in mitotic actomyosin contractile ring assembly and vesicle targeting. Located in cellular bud neck contractile ring; cellular bud tip; and vesicle. Part of MIH complex and myosin II complex. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Orthologous to several human genes including MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MLC1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (306560..307009)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rmd9p Neighboring gene Arc1p Neighboring gene putative sugar transporter

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae. Melino S, et al. J Biomol NMR, 2005 Apr. PMID 15929007
  2. Translation termination factors function outside of translation: yeast eRF1 interacts with myosin light chain, Mlc1p, to effect cytokinesis. Valouev IA, et al. Mol Microbiol, 2004 Jul. PMID 15228544
  3. A molecular dynamics study and free energy analysis of complexes between the Mlc1p protein and two IQ motif peptides. Ganoth A, et al. Biophys J, 2006 Oct 1. PMID 16844751, Free PMC Article
  4. The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae. Altmann K, et al. J Cell Biol, 2008 Apr 7. PMID 18391073, Free PMC Article
  5. N-lobe dynamics of myosin light chain dictates its mode of interaction with myosin V IQ1. Amata I, et al. Biochemistry, 2008 Nov 25. PMID 18975975

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myo1 plays a major role in the septin-dependent Mlc1 localization to the division site before cytokinesis, whereas the formin Bni1 plays a major role in the actin filament-dependent Mlc1 localization during cytokinesis.
    Title: Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis.
  2. Here, we show that the rigid conformation of the loop connecting the two EF-hand motifs of the Mlc1p N-lobe explains its differential ability to interact with myosin V IQ1.
    Title: N-lobe dynamics of myosin light chain dictates its mode of interaction with myosin V IQ1.
  3. myosin light chain 1 (Mlc1p), required for vesicle delivery at the mother-bud neck during cytokinesis, binds to the Myo2p GTD in a region overlapping that of Ypt32p.
    Title: Ypt32p and Mlc1p bind within the vesicle binding region of the class V myosin Myo2p globular tail domain.
  4. Mlc1p/Myo2p interaction is stimulated by a signal that requires Sec2p and activation of Ypt32p
    Title: GTP drives myosin light chain 1 interaction with the class V myosin Myo2 IQ motifs via a Sec2 RabGEF-mediated pathway.
  5. NMR assignment of 1H, 13C and 15N resonances for Mlc1p from Saccharomices cerevisiae
    Title: Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae.
  6. analysis of the interaction of Mlc1p with the first IQ motif of Myo2p
    Title: Structural basis for the interaction of the myosin light chain Mlc1p with the myosin V Myo2p IQ motifs.
  7. mrl1 is a mitochondrial factor for myo2p-dependent inheritance of mitochondria.
    Title: Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast.
  8. the 2-A resolution crystal structure of myosin light chain 1 (Mlc1p) bound to the IQ2-IQ3 fragment of Myo2p, a myosin V from Saccharomyces cerevisiae
    Title: Structure of the light chain-binding domain of myosin V.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin II heavy chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin V binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cell division site involved in mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to cell division site involved in mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle targeting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MIH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MIH complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Mlc1p
NP_011409.1
  • Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    306560..307009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180971.1 → NP_011409.1  TPA: Mlc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU40, P53141
    UniProtKB/TrEMBL
    A6ZU75, B3LHH0, B5VIM0, C7GM01, C8Z8E2, G2WDZ4, N1P3I0
    Conserved Domains (1) summary
    COG5126
    Location:1 → 149
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53141.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous