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YGK1 5'-deoxynucleotidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852777, updated on 18-Sep-2024

Summary

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Official Symbol
YGK1
Official Full Name
5'-deoxynucleotidase
Primary source
SGD:S000003069
Locus tag
YGL101W
See related
AllianceGenome:SGD:S000003069; FungiDB:YGL101W; VEuPathDB:YGL101W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 5'-deoxynucleotidase activity and GMP 5'-nucleotidase activity. Involved in deoxyribonucleoside monophosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YGK1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (312193..312840)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative sugar transporter Neighboring gene ribosomal 60S subunit protein L28 Neighboring gene Seh1p Neighboring gene putative GTPase LSG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of the yeast HD domain containing protein YGK1 reveals a metal-dependent nucleoside 5'-monophosphatase. Yang J, et al. Biochem Biophys Res Commun, 2018 Jun 27. PMID 29752939
  2. Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Lillo JA, et al. Yeast, 2000 Mar 15. PMID 10669874
  3. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
  4. Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Lamb NA, et al. Genetics, 2022 Jul 30. PMID 35686905, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-deoxynucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-deoxynucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables GMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in deoxyribonucleoside monophosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
5'-deoxynucleotidase
NP_011414.1
  • 5'-deoxynucleotidase; non-essential gene involved in deoxyribonucleoside monophosphate degradation; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    312193..312840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180966.1 → NP_011414.1  TPA: 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011414.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU44, P53144
    UniProtKB/TrEMBL
    A6ZU79, B3LHG6, B5VIM4, C7GM19, C8Z8E7, G2WDZ8, N1P9P6
    Conserved Domains (1) summary
    COG1896
    Location:25 → 210
    YfbR; 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53144.1

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