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LSG1 putative GTPase LSG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852779, updated on 18-Sep-2024

Summary

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Official Symbol
LSG1
Official Full Name
putative GTPase LSG1
Primary source
SGD:S000003067
Locus tag
YGL099W
See related
AllianceGenome:SGD:S000003067; FungiDB:YGL099W; VEuPathDB:YGL099W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KRE35
Summary
Enables mRNA binding activity. Involved in ribosomal large subunit assembly and ribosomal subunit export from nucleus. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSG1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (314631..316553)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 5'-deoxynucleotidase Neighboring gene Seh1p Neighboring gene ncRNA Neighboring gene SNAP receptor USE1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1. Jaramillo-Ramírez J, et al. Biochim Biophys Acta Proteins Proteom, 2021 Jan. PMID 32916301
  2. Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. Reynaud EG, et al. BMC Biol, 2005 Oct 7. PMID 16209721, Free PMC Article
  3. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. Hedges J, et al. EMBO J, 2005 Feb 9. PMID 15660131, Free PMC Article
  4. Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit. Hedges J, et al. J Biol Chem, 2006 Dec 1. PMID 17015443
  5. Cytosolic proteostasis through importing of misfolded proteins into mitochondria. Ruan L, et al. Nature, 2017 Mar 16. PMID 28241148, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
    Title: Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
  2. Nmd3 and Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we suggest may activate the GTPase activity of Lsg1.
    Title: Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.
  3. correct loading of Rpl10p into 60S subunits is required for the release of Nmd3p from subunits by Lsg1p
    Title: Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
putative GTPase LSG1
NP_011416.3
  • Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    314631..316553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180964.3 → NP_011416.3  TPA: putative GTPase LSG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011416.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU46, P53145
    UniProtKB/TrEMBL
    G2WE00, N1P5E5
    Conserved Domains (2) summary
    cd01857
    Location:187 → 394
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:167 → 528
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53145.1

Gene LinkOut

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