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DBP3 RNA-dependent ATPase DBP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852802, updated on 3-Nov-2024

Summary

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Official Symbol
DBP3
Official Full Name
RNA-dependent ATPase DBP3
Primary source
SGD:S000003046
Locus tag
YGL078C
See related
AllianceGenome:SGD:S000003046; FungiDB:YGL078C; VEuPathDB:YGL078C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA helicase activity. Involved in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DBP3 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (360288..361859, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pyruvate transporter MPC1 Neighboring gene Kxd1p Neighboring gene Hnm1p Neighboring gene ribosomal 60S subunit protein L7A Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3. Weaver PL, et al. Mol Cell Biol, 1997 Mar. PMID 9032262, Free PMC Article
  2. A Bayesian networks approach for predicting protein-protein interactions from genomic data. Jansen R, et al. Science, 2003 Oct 17. PMID 14564010
  3. Epigenetic memory independent of symmetric histone inheritance. Saxton DS, et al. Elife, 2019 Oct 15. PMID 31613222, Free PMC Article
  4. RNA helicase-mediated regulation of snoRNP dynamics on pre-ribosomes and rRNA 2'-O-methylation. Aquino GRR, et al. Nucleic Acids Res, 2021 Apr 19. PMID 33721027, Free PMC Article
  5. Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. Garcia I, et al. Biochemistry, 2008 Nov 25. PMID 18975973, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-dependent ATPase DBP3
NP_011437.3
  • RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    360288..361859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180943.3 → NP_011437.3  TPA: RNA-dependent ATPase DBP3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011437.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU66, P20447
    UniProtKB/TrEMBL
    C7GW37, N1P1V8
    Conserved Domains (1) summary
    COG0513
    Location:88 → 519
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20447.2

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